Nano-TiO2 aggravates bioaccumulation and developmental neurotoxicity of triphenyl phosphate in zebrafish larvae

文献类型： 外文期刊

第一作者： Fan, Boya

作者： Fan, Boya;Liu, Chunsheng;Sun, Qian;Yu, Liqin;Dai, Lili;Liu, Chunsheng;Yu, Liqin;Liu, Chunsheng;Yu, Liqin

作者机构：

关键词： Triphenyl phosphate; Titanium dioxide nanoparticles; Co-exposure; Neurodevelopmental toxicity; Zebrafish

期刊名称：CHEMOSPHERE （ 影响因子：8.943； 五年影响因子：8.52 ）

ISSN： 0045-6535

年卷期： 2022 年 287 卷

页码：

收录情况： SCI

摘要： This study explored the combined effects of titanium dioxide nanoparticles (nano-TiO2) and triphenyl phosphate (TPhP) on the neurodevelopment of zebrafish larvae as well as the underlying mechanisms. With this regard, zebrafish embryos were exposed to nano-TiO2 of 100 mu g center dot L-1, TPhP of 0, 8, 24, 72, and 144 mu g center dot L-1, or their combinations until 120 h post-fertilization (hpf). Results indicated 100 mu g center dot L-1 nano-TiO2 alone to be nontoxic to zebrafish larvae. However, obvious developmental toxicity manifested as inhibition of surviving rate, heart rate and body length as well as increased malformation was observed in the higher concentrations of TPhP (72 and 144 mu g center dot L-1) alone and the co-exposure groups. Additionally, results suggested that nano-TiO2 significantly enhanced the bioaccumulation of TPhP in zebtafish larvae, and thus aggravated the abnormities of spontaneous movement and swimming behavior in zebrafish larvae induced by TPhP. Nano-TiO2 also exacerbated the TPhPinduced inhibition of the axonal growth on the secondary motor neuron, and aggravated the TPhP-induced decrease on expressions of neuron-specific green fluorescent protein (GFP) and neuronal marker genes (ngn1 and elavl3). Further, the content of neurotransmitter serotonin was not altered by TPhP alone exposure, but was decreased significantly in the co-exposure group of 144 mu g center dot L-1 TPhP and nano-TiO2. Our data indicated that nano-TiO2 might aggravate the neuron abnormities and serotonin system dysfunction by enhancing the TPhP accumulation, leading to exacerbated abnormal locomotors in zebrafish larvae.

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