Multi-omics insights into antioxidant and immune responses in Penaeus monodon under ammonia-N, low salinity, and combined stress

文献类型： 外文期刊

第一作者： Li, Yundong

作者： Li, Yundong;Huang, Sheng;Jiang, Song;Yang, Lishi;Huang, Jianhua;Yang, Qibin;Shi, Jianzhi;Ma, Zhenhua;Zhou, Falin;Li, Yundong;Huang, Sheng;Li, Erchao;Yang, Qibin;Ma, Zhenhua;Zhou, Falin;Li, Yundong;Jiang, Song;Yang, Lishi;Huang, Jianhua;Yang, Qibin;Zhou, Falin;Jiang, Ziyi

作者机构：

关键词： Salinity stress; Ammonia nitrogen stress; Combined stress; Multi-omics; Penaeus monodon

期刊名称：ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY （ 影响因子：6.1； 五年影响因子：6.4 ）

ISSN： 0147-6513

年卷期： 2025 年 295 卷

页码：

收录情况： SCI

摘要： Ammonia nitrogen and salinity are critical environmental factors that significantly impact marine organisms and present substantial threats to Penaeus monodon species within aquaculture systems. This study utilized a comprehensive multi-omics approach, encompassing transcriptomics, metabolomics, and gut microbiome analysis, to systematically examine the biological responses of shrimp subjected to low salinity, ammonia nitrogen stress, and their combined conditions. Metabolomic analysis demonstrated that exposure to ammonia nitrogen stress markedly influenced the concentrations of antioxidant-related metabolites, such as glutathione, suggesting that shrimp mitigate oxidative stress by augmenting their antioxidant capacity. The transcriptomic analysis revealed an upregulation of genes linked to energy metabolism and immune responses and antioxidant enzymes. Concurrently, gut microbiome analysis demonstrated that ammonia nitrogen stress resulted in a marked increase in Vibrio populations and a significant decrease in Photobacterium, indicating that alterations in microbial community structure are intricately associated with the shrimp stress response. A comprehensive analysis further indicated that the combined stressors of ammonia nitrogen and salinity exert a synergistic effect on the immune function and physiological homeostasis of shrimp by modulating antioxidant metabolic pathways and gut microbial communities. These findings provide critical systematic data for elucidating the mechanisms through which ammonia nitrogen and salinity influence marine ecosystems, offering substantial implications for environmental protection and ecological management.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序