Three new naphthoquinone-based meroterpenoids from Streptomyces sp. HBERC-16614 with antibacterial activities

文献类型： 外文期刊

第一作者： Zhang, Ya-Ni

作者： Zhang, Ya-Ni;Liu, Man-Li;Liu, Fang;Zhang, Zhi-Gang;Wu, Zhao-Yuan;Shi, Li-Qiao;Wan, Zhong-Yi;Wang, Yue-Ying;Zhang, Fei;Wang, Kai-Mei;Fang, Wei;Zhang, Ya-Ni;Liu, Man-Li;Liu, Fang;Zhang, Zhi-Gang;Wu, Zhao-Yuan;Shi, Li-Qiao;Wan, Zhong-Yi;Wang, Yue-Ying;Zhang, Fei;Wang, Kai-Mei;Fang, Wei

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关键词： Naphthoquinone-based meroterpenoids; spironaphthomeroterpenoid; naphthablins D and E; antibacterial activities

期刊名称：NATURAL PRODUCT RESEARCH （ 影响因子：1.6； 五年影响因子：2.0 ）

ISSN： 1478-6419

年卷期： 2025 年

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收录情况： SCI

摘要： Three new naphthoquinone-based meroterpenoids (1-3), including spironaphthomeroterpenoid (1), a novel naphthoquinone-based meroterpenoid with a rare [5, 6] spiro-ring skeleton, and naphthablins D and E (2-3), along with three known analogues (4-6) were isolated from Streptomyces sp. HBERC-16614. The structures of these compounds, including their absolute configurations, were established by extensive spectroscopic analysis and electronic circular dichroism (ECD) spectrum. The antibacterial activities of compounds (1-6) were evaluated against Staphylococcus aureus, Streptococcus suis, and Escherichia coli. Among them, compound 1 demonstrated potent antibacterial activity against S. aureus, with a minimum inhibitory concentration (MIC) value of 3.13 mu g/mL.

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