Protective effect of Potentilla anserine polysaccharide (PAP) on hydrogen peroxide induced apoptosis in murine splenic lymphocytes

文献类型: 外文期刊

第一作者: Hu, TingJun

作者: Hu, TingJun;Wei, Xiaojie;Zhang, Ling;Kang, Le;Zhang, Xia;Shuai, XueHong;Cheng, FuSheng

作者机构:

关键词: Potentilla anserine polysaccharide;Lymphocytes;Apoptosis;Hydrogen peroxide

期刊名称:CARBOHYDRATE POLYMERS ( 影响因子:9.381; 五年影响因子:8.678 )

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收录情况: SCI

摘要: The study was carried out to investigate protective effect of Potentilla anserine polysaccharide on the process of apoptosis induced by hydrogen peroxide (H2O2) in murine splenic lymphocytes in vitro. The results showed that apoptosis occured in murine splenic lymphocytes treated with H2O2 in vitro at a concentration of 200 umol/L Treatments with Potentilla anserine polysaccharide at concentrations of 50,100, 200 or 400 μg/mL decreased the amount of apoptosis cells and the anti-apoptosis effect showed a dose dependent manner increase. The results showed that PAP reduced intracellular oxidative damages and dose-dependently inhibited apoptosis. This suggests that PAP is a potential anti-apoptotic agent.

分类号: O629

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