Lentinan Reduces Transmission Efficiency of COVID-19 by Changing Aerodynamic Characteristic of Exhaled SARS-CoV-2 Aerosols in Golden Hamsters

文献类型： 外文期刊

第一作者： Zhang, Cheng

作者： Zhang, Cheng;Cui, Huan;Chen, Zhaoliang;Zhang, Lei;Song, Sihui;Guo, Zhendong;Zhang, Cheng;Cui, Huan;Chen, Zhaoliang;Zhang, Lei;Song, Sihui;Guo, Zhendong;Zhang, Cheng;Cui, Huan;Chen, Zhaoliang;Zhang, Lei;Li, Jiaming;Jin, Yifei;Lu, Bing;Wang, Zhongyi

作者机构：

关键词： lentinan; aerosol transmissibility; exhaled virus aerosols; aerodynamic diameters

期刊名称：MICROORGANISMS （ 影响因子：4.2； 五年影响因子：4.6 ）

ISSN：

年卷期： 2025 年 13 卷 3 期

页码：

收录情况： SCI

摘要： Lentinan (LNT) was found to reduce the aerosol transmission rate between golden hamsters from 100% (9/9) to 44.4% (4/9). The viral loads in the respiratory system, including the nasal turbinate, trachea, and lung, were significantly reduced in the infected golden hamsters that received LNT treatment. Furthermore, the amount of exhaled virus aerosols in hamsters treated with LNT was significantly lower than that in untreated hamsters throughout the entire disease progression. In detail, the amounts of virus-laden particles with aerodynamic diameters less than 5 mu m exhibited a significant decreasing trend following LNT treatment. Moreover, the detection rate of infectious SARS-CoV-2 in each stage of the Anderson-6 sampler exhibited a decreasing trend following LNT treatment post-infection. In summary, our findings indicate that LNT therapy represents a promising therapeutic candidate for the treatment of COVID-19 patients. Meanwhile, during the course of treatment, LNT has the potential to reduce viral infectivity in affected individuals.

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