Bifidobacterium mediate gut microbiota-remedied intestinal barrier damage caused by cyproconazole in zebrafish (Danio rerio)

文献类型： 外文期刊

第一作者： Sun, Xiaoxuan

作者： Sun, Xiaoxuan;Sun, Wei;Miao, Jiyan;Yue, Yifan;Han, Shihang;Huang, Shiran;Diao, Jinling;Zhou, Zhiqiang;Zhu, Wentao;Tian, Sinuo;Yan, Sen;Xu, Ning

作者机构：

关键词： Acetate; Bifidobacterium; Cyproconazole; Gut microbiota; Metabolomics analysis

期刊名称：SCIENCE OF THE TOTAL ENVIRONMENT （ 影响因子：8.2； 五年影响因子：8.6 ）

ISSN： 0048-9697

年卷期： 2024 年 912 卷

页码：

收录情况： SCI

摘要： The widespread use of cyproconazole (CPZ) enhances food security but may pose potential risks to non-target organisms. Therefore, we applied Multi-omics techniques to reveal the response of the intestinal barrier to CPZ exposure and explore whether the Bifidobacterium intervention experiment can repair the damage. First, we found that exposure to CPZ at environmentally relevant concentrations led to intestinal injury phenotype, significantly down-regulated intestinal protein gene expression, and up-regulated pro-inflammatory gene expression, further causing intestinal dysbacteriosis and metabolic disorders. In particular, by combining analysis of gut microbiota and metabolites, we noticed acetate, a key metabolite, which decreased sharply after exposure to high concentration of CPZ. Expectedly, after supplementing with Bifidobacterium (a core bacterium that produces acetate), we noticed that the acetate content was quickly restored. Further, we also verified that the increase in acetate content after Bifidobacterium supplementation at least partially promoted IL-22 secretion, which in turn stimulated the secretion of beta-defensins (zfbd-1, zfbd-2, zfbd-3), thereby repairing the intestinal damage. In conclusion, our work confirms the potential of Bifidobacterium to improve intestinal damage and metabolic dysbiosis caused by CPZ exposure. It provides directional recommendations for the application of probiotics to repair the toxicological risk of pesticide exposure.

分类号：

  • 相关文献
作者其他论文 更多>>
  • Impact of residual antibiotics on microbial decomposition of livestock manures in Eutric Regosol: Implications for sustainable nutrient recycling and soil carbon sequestration

    作者：Fang, Linfa;Lakshmanan, Prakash;Su, Xiaoxuan;Shi, Yujia;Chen, Zheng;Zhang, Yu;Xiao, Ran;Chen, Xinping;Lakshmanan, Prakash;Wu, Junxi;Lakshmanan, Prakash;Lakshmanan, Prakash;Sun, Wei

    关键词：Residual antibiotics; Livestock manure decomposition; Microbial community; Co -occurrence network; Enzyme activities

  • Extreme drought impacts have been underestimated in grasslands and shrublands globally

    作者：Smith, Melinda D.;Knapp, Alan K.;Ohlert, Timothy;Smith, Melinda D.;Knapp, Alan K.;Wilkins, Kate D.;Holdrege, Martin C.;Beard, Karen H.;Kulmatiski, Andrew;Holdrege, Martin C.;Beard, Karen H.;Kulmatiski, Andrew;Wilfahrt, Peter;Anderson, Maggie;Borer, Elizabeth T.;Isbell, Forest;Seabloom, Eric W.;Collins, Scott L.;Sala, Osvaldo E.;Jordan, Samuel;Dukes, Jeffrey S.;Phillips, Richard P.;Beier, Claus;Yahdjian, Laura;Biancari, Lucio;Bondaruk, Viviana Florencia;Onatibia, Gaston R.;Pineiro-Guerra, Juan Manuel;Gherardi, Laureano A.;Larsen, Klaus Steenberg;Fraser, Lauchlan H.;Jentsch, Anke;Niu, Yujie;Loik, Michael E.;Maestre, Fernando T.;Valdecantos, Alejandro;Maestre, Fernando T.;Gozalo, Beatriz;Maturano-Ruiz, Adrian;Valdecantos, Alejandro;Power, Sally A.;Chieppa, Jeff;Nielsen, Uffe N.;Yu, Qiang;Felton, Andrew J.;Munson, Seth M.;Luo, Yiqi;Bauerle, Taryn;Abdoli, Hamed;Abedi, Mehdi;Bahalkeh, Khadijeh;Alados, Concepcion L.;Castillo-Garcia, Miguel;Pueyo, Yolanda;Alberti, Juan;Bruschetti, Carlos Martin;Cardoni, Augusto;Daleo, Pedro;Iribarne, Oscar;Alon, Moshe;Cohen, Ofer;Sternberg, Marcelo;An, Hui;Anacker, Brian;Auge, Harald;Auge, Harald;Eisenhauer, Nico;Hoss, Daniela;Roscher, Christiane;Sunnemann, Marie;Bachle, Seton;Bachle, Seton;Bahn, Michael;Ingrisch, Johannes;Batbaatar, Amgaa;Cahill, James F., Jr.;Batbaatar, Amgaa;Bork, Edward W.;Carlyle, Cameron N.;Behn, Kai;Beil, Ilka;Kreyling, Juergen;Malyshev, Andrey V.;Blindow, Irmgard;Dahlke, Sven;Byrne, Kerry M.;Calvo, Dianela A.;Leder, Cintia V.;Peter, Guadalupe;Carbognani, Michele;Forte, T'ai G. W.;Petraglia, Alessandro;Chang, Scott X.;Cianciaruso, Marcus V.;Guidoni-Martins, Karlo G.;Nobre, Paola;Cordeiro, Amanda L.;Cusack, Daniela F.;Dietterich, Lee H.;D'Antonio, Carla M.;Dietterich, Lee H.;Doherty, Tim S.;Greenville, Aaron C.;Wardle, Glenda M.;Dubbert, Maren;Ebeling, Anne;Eisenhauer, Nico;Fischer, Felicia M.;Hoss, Daniela;Sunnemann, Marie;Hoss, Daniela;Pillar, Valerio D.;Fischer, Felicia M.;Gebauer, Tobias;Anacker, Brian;Haugum, Siri Vatso;Vandvik, Vigdis;Hautier, Yann;Hefting, Mariet;Henry, Hugh A. L.;Johnson, Yari;Kelly, Eugene F.;Kimmel, Kaitlin;Kroel-Dulay, Gyorgy;Orban, Ildiko;Kroel-Dulay, Gyorgy;Orban, Ildiko;Kubert, Angelika;Werner, Christiane;Lamb, Eric G.;Larson, Julie;O'Connor, Rory C.;Lawson, Jason;Plowes, Robert M.;Linstadter, Anja;Orban, Ildiko;Liu, Jielin;Liu, Shirong;Longo, Grisel;Loydi, Alejandro;Rodriguez, Dana Aylen;Scarfo, Maria Cecilia;Luan, Junwei;Wang, Yi;Luan, Junwei;Wang, Yi;Lubbe, Frederick Curtis;Wiehl, Georg;Mackie-Haas, Kathleen;Stampfi, Andreas;Merchant, Thomas;Metcalfe, Daniel B.;Mori, Akira S.;Mori, Akira S.;Mudongo, Edwin;Newman, Gregory S.;Souza, Lara;Nimmo, Dale;Ogaya, Roma;Penuelas, Josep;Osborne, Brooke;Otfinowski, Rafael;Partel, Meelis;Pineiro-Guerra, Juan Manuel;Peri, Pablo L.;Picon-Cochard, Catherine;Pineiro-Guerra, Juan Manuel;Ploughe, Laura W.;Portales-Reyes, Cristy;Reed, Sasha C.;Ritchie, Euan G.;Roscher, Christiane;Sanchez, Ana M.;Santo, Braulio A.;Shi, Baoku;Sun, Wei;Souza, Lara;Standish, Rachel J.;Zeiter, Michaela;Stampfi, Andreas;Zeiter, Michaela;Standish, Rachel J.;Tedder, Michelle;Thorvaldsen, Pal;Tian, Dashuan;Zhu, Juntao;Zong, Ning;Tielborger, Katja;van den Brink, Liesbeth;Vankoughnett, Mathew R.;Velle, Liv Guri;Wang, Changhui;Wei, Cunzheng;Williams, Jennifer L.;Wolf, Amelia A.;Zhang, Fawei;Zuo, Xiaoan;Zuo, Xiaoan;Gebauer, Tobias;Ploughe, Laura W.

    关键词：climate extreme; Drought-Net; International Drought Experiment; productivity

  • Selenium nanoparticle alleviates penthiopyrad-induced oxidative stress and restores the development and flavor quality of tomato fruit

    作者：Liu, Rui;Zhang, Yuting;Li, Bingyan;Liu, Yuping;Pan, Canping;Zhou, Zhiqiang;Diao, Jinling;Pan, Canping

    关键词：Selenium nanoparticle; Oxidative stress; Recovery; Flavor related-genes; Tomato flavor quality

  • miR-329b-5p Affects Sheep Intestinal Epithelial Cells against Escherichia coli F17 Infection

    作者：Xu, Yeling;Chen, Weihao;Sun, Wei;Yang, Huiguo;Song, Zhenghai;Wang, Yeqing;Su, Rui;Mwacharo, Joram M.;Lv, Xiaoyang;Sun, Wei;Lv, Xiaoyang;Sun, Wei

    关键词：Escherichia coli F17; micro RNA; sheep diarrhea; intestinal epithelial cells

  • Integrated assessment of the spatial distribution, sources, degradation, and human risk of tetracyclines in honey in China

    作者：Wang, Xinran;Luan, Yunxia;Tian, Sinuo;Li, Cheng;Wang, Xinran;Li, Yi;Zhou, Jinhui;Dong, Yiwei;Li, Yi;Zhou, Jinhui

    关键词：Honey; Tetracyclines; Spatial distribution; Degradation patterns; Risk assessment

  • Gene pyramiding of ZmGLK36 and ZmGDIα-hel for rough dwarf disease resistance in maize

    作者：Li, Gongjian;Zhao, Jiqiang;Li, Gongjian;Xu, Zhennan;Zhou, Zhiqiang;Li, Mingshun;Hao, Zhuanfang;Zhang, Degui;Yong, Hongjun;Han, Jienan;Li, Xinhai;Weng, Jianfeng;Wang, Jianjun;Mu, Chunhua

    关键词：Maize; Maize rough dwarf disease (MRDD); ZmGLK36; ZmGDI alpha-hel; Gene pyramiding

  • Variations in antibiotic resistomes associated with archaeal, bacterial, and viral communities affected by integrated rice-fish farming in the paddy field ecosystem

    作者：Hou, Yiran;Jia, Rui;Sun, Wei;Feng, Wenrong;Li, Bing;Zhu, Jian;Hou, Yiran;Diao, Weixu;Jia, Rui;Feng, Wenrong;Li, Bing;Zhu, Jian

    关键词：Antibiotic resistomes; Antibiotic resistance genes (ARGs); Agricultural production patterns; Clean and sustainable agricultural production; Integrated rice-fish farming; Paddy field; Archaeal; Bacterial; And viral communities

微信小程序