A goat poxvirus-vectored peste-des-petits-ruminants vaccine induces long-lasting neutralization antibody to high levels in goats and sheep

文献类型： 外文期刊

第一作者： Chen, Weiye

作者： Chen, Weiye;Hu, Sen;Qu, Linmao;Hu, Qianqian;Zhang, Qian;Bu, Zhigao;Chen, Weiye;Hu, Sen;Qu, Linmao;Hu, Qianqian;Zhang, Qian;Bu, Zhigao;Qu, Linmao;Hu, Qianqian;Huang, Kehe;Zhi, Haibing

作者机构：

关键词： glycoprotein H;glycoprotein F;viral neutralization antibody;goat poxvirus-vectored peste-des-petits-ruminant vaccine: immunologic-drug;vaccine

期刊名称：VACCINE （ 影响因子：3.641； 五年影响因子：3.816 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： Recombinant capripoxvirus (CPV) is a promising candidate differentiating infected from vaccinated animals (DIVA) vaccine against peste-des-petits-ruminants (PPR). In order for recombinant CPV to be successfully used in the field, there should exist dependable indicators for quality control of vaccine products, surveillance and vaccination evaluation. Viral neutralization antibody (VNA) is correlated to protection against PPR and is a technically feasible indicator for this purpose. The immunogenicity of this vectored vaccine in goats and sheep, however, has not been fully evaluated. In this study, we generated two recombinant CPV viruses, rCPV-PPRVH and rCPV-PPRVF, that express PPR virus (PPRV) glycoproteins H and F, respectively. Vaccination studies with different dosages of recombinant viruses showed that rCPV-PPRVH was a more potent inducer of PPRV VNA than rCPV-PPRVF. One dose of rCPV-PPRVH was enough to seroconvert 80% of immunized sheep. A second dose induced significantly higher PPRV VNA titers. There was no significant difference in PPRV VNA responses between goats and sheep. Subcutaneous inoculation also induced a significant PPRV VNA response. PPRV VNA could be detected for over 6 months in more than 80% of vaccinated goats and sheep. Boost vaccination at 6-month intervals induced significant re-boost efficacy of PPRV VNA in goats and sheep. More over, two doses of rCPV-PPRVH could completely overcome the interference caused by pre-existing immunity to the CPV vaccine backbone in animals. Vaccination with rCPV-PPRVH also protected goats from virulent CPV challenge. Our results demonstrate that VNA can serve as a dependent indicator for effective vaccination and immune protection of animals in the field. The recombinant CPV vaccine used in our studies could be a practical and useful candidate DIVA vaccine in countries where PPR newly emerges or where stamp-out plans are yet to be implemented

分类号： R392

  • 相关文献

[1]A multivalent killed whole-cell vaccine induces effective protection against Edwardsiella tarda and Vibrio anguillarum. Sun, Yun,Sun, Li,Liu, Chun-sheng,Sun, Yun.

[2]Comparative study of the immune effect of an Edwardsiella tarda antigen in two forms: Subunit vaccine vs DNA vaccine. Sun, Yun,Sun, Li,Sun, Yun,Liu, Chun-Sheng.

[3]Development of DIVA (differentiation of infected from vaccinated animals) vaccines utilizing heterologous NA and NS1 protein strategies for the control of triple reassortant H3N2 influenza in turkeys. Wang, Leyi,Qin, Zhuoming,Saifa, Yehia M.,Lee, Chang-Won,Wang, Leyi,Saifa, Yehia M.,Lee, Chang-Won,Qin, Zhuoming,Pantin-Jackwood, Mary,Faulkner, Olivia,Suarez, David L.,Garcia, Maricarmen,Lupiani, Blanca,Reddy, Sanjay M.. 2011

[4]Genomic analysis of an effective lentiviral vaccine-attenuated equine infectious anemia virus vaccine EIAV(FDDV13). Qi, Xu,Su, Zhiqiang,Wang, Xuefeng,Wang, Shuai,Lin, Yuezhi,Jiang, Chenggang,Ma, Jian,Zhao, Liping,Lv, Xiaoling,Shen, Rongxian,Kong, Xiangang,Zhou, Jianhua,Wang, Xuefeng,Wang, Fenglong,Ma, Jian. 2010

[5]Single Dose of Consensus Hemagglutinin-Based Virus-Like Particles Vaccine Protects Chickens against Divergent H5 Subtype Influenza Viruses. Wu, Peipei,Lu, Jihu,Zhang, Xuehua,Mei, Mei,Feng, Lei,Hou, Jibo,Tang, Yinghua,Wu, Peipei,Lu, Jihu,Zhang, Xuehua,Mei, Mei,Feng, Lei,Hou, Jibo,Tang, Yinghua,Wu, Peipei,Lu, Jihu,Zhang, Xuehua,Mei, Mei,Feng, Lei,Peng, Daxin,Hou, Jibo,Liu, Xiufan,Tang, Yinghua,Peng, Daxin,Liu, Xiufan,Kang, Sang-Moo. 2017

[6]Paving the way to construct a new vaccine against Escherichia coli from its recombinant outer membrane protein C via a murine model. Wang, Xiao,Guan, Qingfeng,Wang, Xiumin,Teng, Da,Mao, Ruoyu,Wang, Jianhua,Wang, Xiao,Yao, Junhu,Wang, Xiao,Guan, Qingfeng,Wang, Xiumin,Teng, Da,Mao, Ruoyu,Wang, Jianhua. 2015

[7]Recombinant Marek's Disease Virus as a Vector-Based Vaccine against Avian Leukosis Virus Subgroup J in Chicken. Liu, Yongzhen,Li, Kai,Gao, Yulong,Gao, Li,Zhong, Li,Zhang, Yao,Liu, Changjun,Zhang, Yanping,Wang, Xiaomei. 2016

[8]Early immunocastration of male pigs with Improvac (R) - Effect on boar taint, hormones and reproductive organs. Brunius, Carl,Zamaratskaia, Galia,Lundstrom, Kerstin,Andersson, Kristina,Chen, Gang,Norrby, Mattias,Madej, Andrzej. 2011

[9]A subunit vaccine candidate derived from a classic H5N1 avian influenza virus in China protects fowls and BALB/c mice from lethal challenge. Liu, Guangliang,Zhang, Fangfang,Shi, Jianzhong,Tian, Guobing,Chen, Hualan,Yu, Kangzheng,Meng, Qingwen. 2013

[10]The Taishan Robinia pseudoacacia polysaccharides enhance immune effects of rabbit haemorrhagic disease virus inactivated vaccines. Yang, Shifa,Li, Guiming,Zhao, Zengcheng,Feng, Minyan,Fu, Jian,Huang, Zhongli,Song, Minxun,Lin, Shuqian. 2017

[11]Mucosal Immune Responses against Live Newcastle Disease Vaccine in Immunosuppressed Chickens. Yan, Zhengui,Zhao, Qingyou,Fan, Ruifeng,Guo, Wenlong,Ma, Rongde,Wang, Xinjian,Zhu, Ruiliang,Du, Yijun. 2011

[12]Self-assembly of virus-like particles of rabbit hemorrhagic disease virus capsid protein expressed in Escherichia coli and their immunogenicity in rabbits. Guo, Huimin,Zhu, Jie,Tan, Yonggui,Li, Chuanfeng,Chen, Zongyan,Liu, Guangqing,Sun, Shiqi.

[13]Establishment of Eimeria tenella (local isolate) in chicken embryos. Jiang, L.,Zhao, Q.,Zhu, S.,Han, H.,Dong, H.,Huang, B..

[14]Protein encoded by ORF093 is an effective vaccine candidate for infectious spleen and kidney necrosis virus in Chinese perch Siniperca chuatsi. Li, Ningqiu,Fu, Xiaozhe,Guo, Huizhi,Lin, Qiang,Liu, Lihui,Zhang, Defeng,Fang, Xiang,Wu, Shuqin,Li, Ningqiu,Fu, Xiaozhe,Guo, Huizhi,Lin, Qiang,Liu, Lihui,Zhang, Defeng,Fang, Xiang,Wu, Shuqin.

[15]Development and immunogenicity of a recombinant pseudorabies virus expressing Sj26GST and SjFABP from Schistosoma japonicum. Wei, Feng,Zhai, Yujia,Jin, Hongtao,Shang, Limin,Men, Jingtao,Liu, Quan,Gao, Hongwei,Wei, Feng,Lin, Jiaojiao,Fu, Zhiqiang,Shi, Yaojun,Zhu, Xing-Quan.

[16]Classical swine fever in China: A minireview. Luo, Yuzi,Li, Su,Sun, Yuan,Qiu, Hua-Ji.

[17]Effects of dietary vitamin E on immunological stress of layers and their offspring. Zhao, G. P.,Han, M. J.,Zheng, M. Q.,Zhao, J. P.,Chen, J. L.,Wen, J..

[18]An infectious cDNA clone of a highly pathogenic porcine reproductive and respiratory syndrome virus variant associated with porcine high fever syndrome. Lv, Jian,Zhan, Jianwu,Sun, Zhi,Yuan, Shishan,Lv, Jian,Liu, Weiquan.

[19]Development and efficacy of a novel streptomycin-resistant Flavobacterium johnsoniae vaccine in grass carp (Ctenopharyngodon idella). Li, Ningqiu,Lin, Qiang,Fu, Xiaozhe,Guo, Huizhi,Liu, Lihui,Wu, Shuqin,Li, Ningqiu,Li, Ningqiu,Lin, Qiang,Fu, Xiaozhe,Guo, Huizhi,Liu, Lihui,Wu, Shuqin.

[20]Effect of VP28 DNA vaccine on white spot syndrome virus in Litopenaeus vannamei. Li, Xiang,Liu, Qing-hui,Huang, Jie,Li, Xiang,Hou, Lin.

作者其他论文 更多>>

微信小程序