Podophyllotoxin derivatives show activity against Brontispa longissima larvae

文献类型： 外文期刊

第一作者： Liu, Ying-Qian

作者： Liu, Ying-Qian;Zhang, Jing;Feng, Gang;Yang, Liu

作者机构：

关键词： Brontispa longissima;Insecticidal activity;Podophyllotoxin;Structure-activity relationships

期刊名称：NATURAL PRODUCT COMMUNICATIONS （ 影响因子：0.986； 五年影响因子：1.068 ）

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年卷期：

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收录情况： SCI

摘要： In an attempt to find biorational insecticides, eleven podophyllotoxin analogues were tested for their insecticidal activity against the fifth-instar larvae of Brontispa longissima in vivo for the first time. Among all of the tested compounds, deoxypodophyllotoxin (3) and β-apopicropodophyllin (4) showed more promising and pronounced insecticidal activity than toosendanin, a commercial insecticide derived from Melia toosendan, and important SAR information has been revealed. Together, these preliminary results may be useful in guiding further modification of podophyllotoxins in the development of potential new insecticides.

分类号： N

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