Oocytes maintain low ROS levels to support the dormancy of primordial follicles

文献类型： 外文期刊

第一作者： Qin, Shaogang

作者： Qin, Shaogang;Chi, Xinyue;Zhu, Zijian;Gao, Meng;Zhao, Ting;Zhang, Jingwen;Zheng, Wenying;Chen, Ziqi;Zhou, Bo;Xia, Guoliang;Wang, Chao;Chen, Chuanhe;Zhang, Tuo;He, Meina;Zhang, Lifan;Wang, Wenji

作者机构：

关键词： ferroptosis; primary ovarian insufficiency; primordial follicle; ROS; SOD1

期刊名称：AGING CELL （ 影响因子：7.1； 五年影响因子：8.9 ）

ISSN： 1474-9718

年卷期： 2025 年 24 卷 1 期

页码：

收录情况： SCI

摘要： Primordial follicles (PFs) function as the long-term reserve for female reproduction, remaining dormant in the ovaries and becoming progressively depleted with age. Oxidative stress plays an important role in promoting female reproductive senescence during aging, but the underlying mechanisms remain unclear. Here, we find that low levels of reactive oxygen species (ROS) are essential for sustaining PF dormancy. Compared to growing follicles, oocytes within PFs were shown to be more susceptible to ROS, which accumulates and damages PFs to promote reproductive senescence. Mechanistically, oocytes within PFs were shown to express high levels of the intracellular antioxidant enzyme superoxide dismutase 1 (SOD1), counteracting ROS accumulation. Decreased SOD1 expression, as a result of aging or through the experimental deletion of the Sod1 gene in oocytes, resulted in increased oxidative stress and triggered ferroptosis within PFs. In conclusion, this study identified antioxidant defense mechanisms protecting PFs in mouse ovaries and characterized cell death mechanisms of oxidative stress-induced PF death.

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