One health genomic insights into the host-specific evolution and cross-host transmission of Staphylococcus aureus in animal farm environments, food of animal origin, and humans

文献类型： 外文期刊

第一作者： Pan, Yu

作者： Pan, Yu;Chen, Lin;Li, Guihua;Hu, Jianxin;Liu, Weiqi;Zeng, Zhenling;Pan, Yu;Chen, Lin;Zhang, Lingxuan;Zeng, Jiaxiong;Zeng, Zhenling;Zeng, Jiaxiong;Li, Yafei;Zeng, Zhenling;Li, Yafei

作者机构： South China Agr Univ, Coll Vet Med, Natl Risk Assessment Lab Antimicrobial Resistant M, Guangdong Prov Key Lab Vet Pharmaceut Dev & Safety, Guangzhou, Peoples R China;Guangdong Lab Lingnan Modern Agr, Guangzhou, Peoples R China;Sun Yat Sen Univ, Sch Environm Sci & Engn, Guangzhou, Peoples R China;Guangdong Acad Agr Sci, Inst Qual Stand Monitoring Technol Agroprod, Guangzhou, Peoples R China;483 Wushan Rd, Guangzhou 510642, Peoples R China;29 Jinying Rd, Guangzhou 510640, Peoples R China

关键词： Staphylococcus aureus; Whole-genome sequencing; One Health surveillance; Antibiotic resistance; Public health

期刊名称：INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS （ 2022影响因子：10.8； 五年影响因子：7.2 ）

ISSN： 0924-8579

年卷期： 2023 年 62 卷 4 期

页码：

收录情况： SCI

摘要： Objectives: Staphylococcus aureus is an opportunistic pathogen that is considered a high priority for research. However, comparative studies of S. aureus strains from different environments and hosts are still lacking.Methods: Here, we performed a high-resolution bioinformatics analysis of 576 S. aureus genomes isolated from livestock, farm environments, farm workers, animal-origin food, and humans. Results: The S. aureus isolates showed high diversity in genetic lineages and demonstrated host specialization and multi-host range in the population phylogeny. Recent transmission events, historical divergences, and frequent host switching in specific sequence types (STs) and through the food chain and animal farm mediums were observed. Frequent gene transfer may quickly give rise to new fitness to colonize their host or switch to other hosts, even in isolates with the closest vertical evolutionary history. The large multi-host-shared antibiotic resistance gene (ARG) pool was the major factor shaping antibiotic resistance in S. aureus isolates. We revealed the genetic backgrounds of mec, cfr , and optrA , which could be spread among isolates from different species, hosts, and environments.Conclusion: Overall, our findings provide One Health genomic insights into the evolution, transmission, gene content characteristics, and antibiotic resistance profiles of S. aureus from different hosts, suggesting that, despite well-formed host specificity during the evolution of S. aureus , the ever-expanding host range and the cross-hosts/niches transmission (at both the strain and genetic level) may be facilitated by diverse bacterial vehicles (e.g., food chain, farm environments, and workers), which will lead to emerging antibiotic resistance consequences and threaten public health and food safety.& COPY; 2023 Elsevier Ltd and International Society of Antimicrobial Chemotherapy. All rights reserved.

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