Nanozyme-strip based on MnO2 nanosheets as a catalytic label for multi-scale detection of aflatoxin B-1 with an ultrabroad working range

文献类型： 外文期刊

第一作者： Cai, Xinfa

作者： Cai, Xinfa;Liang, Meijuan;Ma, Fei;Zhang, Zhaowei;Tang, Xiaoqian;Jiang, Jun;Guo, Can;Yu, Li;Li, Peiwu;Cai, Xinfa;Liang, Meijuan;Ma, Fei;Zhang, Zhaowei;Tang, Xiaoqian;Jiang, Jun;Guo, Can;Yu, Li;Li, Peiwu;Cai, Xinfa;Liang, Meijuan;Ma, Fei;Zhang, Zhaowei;Tang, Xiaoqian;Jiang, Jun;Guo, Can;Yu, Li;Li, Peiwu;Jiang, Jun;Guo, Can;Yu, Li;Li, Peiwu;Jiang, Jun;Guo, Can;Yu, Li;Li, Peiwu;Mohamed, Sherif Ramzy;Goda, Amira Abdel;Dawood, Dawood H.

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关键词： Aflatoxin B-1; Nanozyme; Oxidase mimic; MnO2 nanosheets; Multi-scale detection; Ultrabroad working range

期刊名称：FOOD CHEMISTRY （ 影响因子：9.231； 五年影响因子：8.795 ）

ISSN： 0308-8146

年卷期： 2022 年 377 卷

页码：

收录情况： SCI

摘要： Lateral flow immunoassay (LFIA) is the most effective real-time detection method for aflatoxin B-1 (AFB(1)). Here, we constructed a nanozyme-strip based on MnO2 nanosheets (MnO2 NSs) as a catalytic label for detection of AFB(1). By taking advantage of the MnO2-TMB catalytic amplified system, the new test achieves rapid detection with high sensitivity and ultrawide range. The limit of detection of the assay was 15 pg mL(-1), which was over 100-fold lower than the maximum limit set by the European Union (EU) of AFB(1) in foods. In addition, the strip test could offer 7 dynamic detection ranges, spanning 4 orders of magnitude, which could cater to the varieties of limits on AFB1 residues in foods and feeds set by different countries. The estimated recoveries were in the range of 85.67%-106.38% with coefficients of variations (CVs) less than 9.68%. Overall, the developed approach is a rapid, reliable, sensitive and widely available tool for on-site detection of AFB(1).

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