Genetic Properties of the Maize Nested Association Mapping Population

文献类型： 外文期刊

第一作者： McMullen, Michael D.

作者： McMullen, Michael D.;Bradbury, Peter;Flint-Garcia, Sherry;Browne, Chris;Eller, Magen;Guill, Kate;Lepak, Nick;Peterson, Brooke;Romero, Susan;Salvo, Stella;Ware, Doreen;Holland, James B.;Buckler, Edward S.;McMullen, Michael D.;Villeda, Hector Sanchez;Flint-Garcia, Sherry;Bottoms, Christopher;Kresovich, Stephen;Bradbury, Peter;Li, Huihui;Acharya, Charlotte;Brown, Patrick;Harjes, Carlos;Kroon, Dallas;Mitchell, Sharon E.;Pressoir, Gael;Yates, Heather;Buckler, Edward S.;Li, Huihui;Li, Huihui;Sun, Qi;Thornsberry, Jeffry;Rosas, Marco Oropeza;Goodman, Major;Holland, James B.;Hanson, Mark;Jones, Elizabeth;Smith, Stephen;Glaubitz, Jeffrey C.;Ware, Doreen;Buckler, Edward S.

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期刊名称：SCIENCE （ 影响因子：47.728； 五年影响因子：51.433 ）

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收录情况： SCI

摘要： Maize genetic diversity has been used to understand the molecular basis of phenotypic variation and to improve agricultural efficiency and sustainability. We crossed 25 diverse inbred maize lines to the B73 reference line, capturing a total of 136,000 recombination events. Variation for recombination frequencies was observed among families, influenced by local (cis) genetic variation. We identified evidence for numerous minor single-locus effects but little two-locus linkage disequilibrium or segregation distortion, which indicated a limited role for genes with large effects and epistatic interactions on fitness. We observed excess residual heterozygosity in pericentromeric regions, which suggested that selection in inbred lines has been less efficient in these regions because of reduced recombination frequency. This implies that pericentromeric regions may contribute disproportionally to heterosis.

分类号： N

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