Metal-organic framework-mediated antioxidant enzyme delivery in disease treatment

文献类型： 外文期刊

第一作者： Yayun, Jiang

作者： Yayun, Jiang;Qianqian, Ge;Yuying, Li;Qian, Jiang;Yayun, Jiang;Qianqian, Ge;Xihang, Sun;Zhenping, Hou;Yuying, Li;Pengjun, Shi;Yang, Hong;Xiancheng, Ma;Yuying, Li;Pengjun, Shi

作者机构：

关键词： Antioxidant enzymes; Reactive oxygen species; Oxidative stress; Metal-organic frameworks; Drug delivery; Oxidative stress-related diseases

期刊名称：REDOX BIOLOGY （ 影响因子：11.9； 五年影响因子：13.1 ）

ISSN： 2213-2317

年卷期： 2025 年 85 卷

页码：

收录情况： SCI

摘要： Excessive reactive oxygen species (ROS) induce oxidative stress (OS), resulting in biomolecular damage. ROS are closely linked to diseases such as inflammatory bowel disease (IBD), diabetes, and cancer. Antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), and glucose oxidase (GOX) play crucial roles in alleviating OS by effectively reducing ROS levels through synergistic action. However, these antioxidant enzymes exhibit poor stability in complex biological environments and lack adequate targeting capability, thereby limiting their applications in disease treatment. Metal-organic frameworks (MOFs) serve as carriers that significantly enhance enzyme stability and targeting ability, thereby boosting catalytic efficiency and therapeutic outcomes. This review discusses the classification of antioxidant enzymes and their role in ROS regulation, the types and physicochemical properties of MOFs, and the assembly methods of enzyme@MOF systems. Furthermore, it examines the potential of integrating MOFs with antioxidant enzymes for the treatment of diseases associated with OS. Although the strategy of enzyme immobilization with MOFs shows great application prospects, further optimization is required in terms of biocompatibility, long-term stability, and delivery efficiency to promote the clinical translation of these results.

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