Volvalerenone A, a new type of mononorsesquiterpenoid with an unprecedented 3,12-oxo bridge from Valeriana officinalis

文献类型： 外文期刊

第一作者： Wang, Peng-Cheng

作者： Wang, Peng-Cheng;Ran, Xin-Hui;Chen, Rui;Liu, Yu-Qing;Luo, Huai-Rong;Zhou, Jun;Zhao, You-Xing;Zhao, You-Xing;Wang, Peng-Cheng;Li, Liang-Chun;Xiong, Shan-Shan

作者机构：

关键词： Valeriana officinalis;Valerianacae;Mononorsesquiterpenoid;Volvalerenone A;AChE inhibitory activity

期刊名称：TETRAHEDRON LETTERS （ 影响因子：2.415； 五年影响因子：2.036 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： Volvalerenone A (1), a new type of mononorsesquiterpenoid with an unprecedented 5/6/6 tricyclic ring system, was isolated from the roots of Valeriana officinalis, the official species of valerian used in Europe. The structure of volvalerenone A was elucidated based on its spectroscopic and single-crystal X-ray crystallography data. The absolute configuration was assigned by the computational method. A possible bio-synthetic pathway of volvalerenone A was also proposed. Preliminary biological studies showed that volvalerenone A had weak inhibitory activity on acetylcholine esterase (AChE), and no enhancing activity on nerve growth factor (NGF)-mediated neurite outgrowth in PCI 2 cells was observed at 50 uM.

分类号： O62

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