Bile acids and their receptors in regulation of gut health and diseases

文献类型： 外文期刊

第一作者： Lin, Sen

作者： Lin, Sen;Wu, De;Fang, Zhengfeng;Lin, Sen;Tang, Cuiming;Wang, Zhenjiang;Chen, Lian;Luo, Guoqing;Wang, Sutian;Wang, Peng;Chen, Hong;Liu, Yuntao;Feng, Bin;Fang, Zhengfeng;Burrin, Douglas G.

作者机构：

关键词： Bile acids; FXR; GPBAR1; Inflammatory bowel diseases; Colorectal cancers

期刊名称：PROGRESS IN LIPID RESEARCH （ 影响因子：13.6； 五年影响因子：16.1 ）

ISSN： 0163-7827

年卷期： 2023 年 89 卷

页码：

收录情况： SCI

摘要： It is well established that bile acids play important roles in lipid metabolism. In recent decades, bile acids have also been shown to function as signaling molecules via interacting with various receptors. Bile acids circulate continuously through the enterohepatic circulation and go through microbial transformation by gut microbes, and thus bile acids metabolism has profound effects on the liver and intestinal tissues as well as the gut microbiota. Farnesoid X receptor and G protein-coupled bile acid receptor 1 are two pivotal bile acid receptors that highly expressed in the intestinal tissues, and they have emerged as pivotal regulators in bile acids metabolism, innate immunity and inflammatory responses. There is considerable interest in manipulating the metabolism of bile acids and the expression of bile acid receptors as this may be a promising strategy to regulate intestinal health and disease. This review aims to summarize the roles of bile acids and their receptors in regulation of gut health and diseases.

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