Barriers and opportunities in pancreatic cancer immunotherapy

文献类型： 外文期刊

第一作者： Ju, Yixin

作者： Ju, Yixin;Xu, Dongzhi;Liao, Miao-miao;Bao, Wen-dai;Yao, Fan;Ju, Yixin;Xu, Dongzhi;Yao, Fan;Sun, Yutong;Yao, Fan;Ma, Li;Ma, Li

作者机构：

期刊名称：NPJ PRECISION ONCOLOGY （ 影响因子：8.0； 五年影响因子：8.0 ）

ISSN：

年卷期： 2024 年 8 卷 1 期

页码：

收录情况： SCI

摘要： Pancreatic ductal adenocarcinoma (PDAC) presents a fatal clinical challenge characterized by a dismal 5-year overall survival rate, primarily due to the lack of early diagnosis and limited therapeutic efficacy. Immunotherapy, a proven success in multiple cancers, has yet to demonstrate significant benefits in PDAC. Recent studies have revealed the immunosuppressive characteristics of the PDAC tumor microenvironment (TME), including immune cells with suppressive properties, desmoplastic stroma, microbiome influences, and PDAC-specific signaling pathways. In this article, we review recent advances in understanding the immunosuppressive TME of PDAC, TME differences among various mouse models of pancreatic cancer, and the mechanisms underlying resistance to immunotherapeutic interventions. Furthermore, we discuss the potential of targeting cancer cell-intrinsic pathways and TME components to sensitize PDAC to immune therapies, providing insights into strategies and future perspectives to break through the barriers in improving pancreatic cancer treatment.

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