Glycosylated proteins with abnormal glycosylation changes are potential biomarkers for early diagnosis of breast cancer

文献类型： 外文期刊

第一作者： Chang, Xinyu

作者： Chang, Xinyu;Obianwuna, Uchechukwu Edna;Wang, Jing;Zhang, Haijun;Qi, Guanghai;Qiu, Kai;Wu, Shugeng

作者机构：

关键词： Breast cancer; Glycosylation; Glycan; Biomarkers

期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：8.2； 五年影响因子：7.8 ）

ISSN： 0141-8130

年卷期： 2023 年 236 卷

页码：

收录情况： SCI

摘要： Conventional cancer management relies on tumor type and stage for diagnosis and treatment, which leads to recurrence and metastasis and death in young women. Early detection of proteins in the serum aids diagnosis, progression, and clinical outcomes, possibly improving survival rate of breast cancer patients. In this review, we provided an insight into the influence of aberrant glycosylation on breast cancer development and progression. Examined literatures revealed that mechanisms underlying glycosylation moieties alteration could enhance early detection, monitoring, and therapeutic efficacy in breast cancer patients. This would serve as a guide for the development of new serum biomarkers with higher sensitivity and specificity, providing possible serological biomarkers for breast cancer diagnosis, progression, and treatment.

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