Lanostane Triterpenes from the Tibetan Medicinal Mushroom Ganoderma leucocontextum and Their Inhibitory Effects on HMG-CoA Reductase and alpha-Glucosidase

文献类型： 外文期刊

第一作者： Wang, Kai

作者： Wang, Kai;Bao, Li;Ma, Ke;Han, Junjie;Wang, Wenzhao;Yin, Wenbing;Liu, Hongwei;Wang, Kai;Xiong, Weiping

作者机构：

期刊名称：JOURNAL OF NATURAL PRODUCTS （ 影响因子：4.803； 五年影响因子：4.869 ）

ISSN： 0163-3864

年卷期： 2015 年 78 卷 8 期

页码：

收录情况： SCI

摘要： Sixteen new lanostane triterpenes, ganoleucoins A-P (1-16), together with 10 known tripterpenes (17-26), were isolated from the cultivated fruiting bodies of Ganoderma leucocontextum, a new member of the Ganoderma lucidum complex. The structures of the new compounds were elucidated by extensive spectroscopic analysis and chemical transformation. The inhibitory effects of 1-26 on HMG-CoA reductase and a-glucosidase were tested in vitro. Compounds 1, 3, 6, 10-14, 17, 18, 23, 25, and 26 showed much stronger inhibitory activity against HMG-CoA reductase than the positive control atorvastatin. Compounds 13, 14, and 16 presented potent inhibitory activity against a-glucosidase from yeast with IC50 values of 13.6, 2.5, and 5.9 mu M, respectively. In addition, the cytotoxicity of 1-26 was evaluated against the K562 and PC-3 cell lines by the MTT assay. Compounds 1, 2, 6, 7, 10, 12, 16, 18, and 25 exhibited cytotoxicity against K562 cells with IC50 values in the range 10-20 mu M. Paclitaxel was used as the positive control with an IC50 value of 0.9 mu M. This is the first report of secondary metabolites from this medicinal mushroom.

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