Sex-specific thyroid disruption caused by phenanthrene in adult zebrafish (Danio rerio)

文献类型： 外文期刊

第一作者： Zhong, Liqiao

作者： Zhong, Liqiao;Wu, Luyin;Ru, Huijun;Wei, Nian;Yao, Fan;Ni, Zhaohui;Duan, Xinbin;Li, Yunfeng;Wu, Luyin;Zhang, He

作者机构：

关键词： Phenanthrene; Adult zebrafish; Thyroid disruption; Hypothalamic-pituitary-thyroid axis; Sex-specific

期刊名称：COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY （ 影响因子：4.52； 五年影响因子：4.203 ）

ISSN： 1532-0456

年卷期： 2023 年 263 卷

页码：

收录情况： SCI

摘要： Polycyclic aromatic hydrocarbons (PAHs) are well-known contaminants with widespread distribution in envi-ronment and food. Phenanthrene is one of the most abundant PAHs in food and aquatic environment and generates reproductive and developmental toxicity in zebrafish. Nonetheless, whether phenanthrene caused sex -specific thyroid disruption in adult zebrafish is unclear. To determine this, adult zebrafish (male and female) were treated with phenanthrene (0, 0.85, 8.5, and 85 mu g/L) for 60 days. After the treatment period, we assessed the concentrations of thyroid hormones (THs) and expression levels of genes in the hypothalamic-pituitary -thyroid (HPT) axis. The results showed that phenanthrene exposure can lead to thyroid disruption in both male and female zebrafish. Exposure to phenanthrene dramatically reduced the levels of L-thyroxine (T4) and L-triiodothyronine (T3) in both male and female zebrafish, with a similar trend in both. However, the genes expression profiles of hypothalamic-pituitary-thyroid (HPT) axis were sex-specific. In all, the present study demonstrated that phenanthrene exposure could result in sex-specific thyroid disruption in adult zebrafish.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序