文献类型： 外文期刊
第一作者： Olajide, Joshua S.
作者： Olajide, Joshua S.;Qu, Zigang;Yang, Shunli;Yang, Bin;Xu, Xiao;Wang, Jing;Cai, Jianping;Olajide, Joshua S.;Yang, Shunli;Qu, Zigang;Cai, Jianping
作者机构：
关键词： Apicomplexa; circRNA; Eimeria falciformis; extracellular vesicles; host-parasite interaction; lncRNA
期刊名称：JOURNAL OF EUKARYOTIC MICROBIOLOGY （ 影响因子：2.2； 五年影响因子：2.4 ）
ISSN： 1066-5234
年卷期： 2023 年
页码：
收录情况： SCI
摘要： Long noncoding RNAs (lncRNAs) are regulatory transcripts during protozoan infections in the host intestinal epithelial cells (IECs). Apicomplexan Eimeria falciformis sporozoite extracellular vesicles (EVs) contain virulence factors that modulate host IECs pro-inflammatory genes and immune responses. In this study, E. falciformis sporozoites were made to interact with inactivated host cells, and the parasite EVs were separated from total secretome by ultracentrifugation and purified on density gradient medium. Dose-dependent bio-activity of E. falciformis EVs was investigated by RNA sequencing, functional annotation and quantitative PCR. It was found that E. falciformis EVs induced mRNA, circRNA, and lncRNA expressions in mouse IECs. Of 38, 217 lncRNAs assembled, 157 and 152 were upwardly and downwardly expressed respectively. Differentially expressed lncRNAs were associated with cytokines, pyroptosis, and immune signaling pathways including FoxO, NF-kappa B, MAPK, and TGF-beta. In essence, E. falciformis EVs altered host cell RNA expressions during the interaction with host IECs. Also, differentially expressed lncRNAs are potential diagnostic transcripts during Eimeria infections.
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