Bioactive Hydrogel Dressing with Inherent Antimicrobial and Antioxidant Activity for Wound Healing

文献类型： 外文期刊

第一作者： Gao, Zilong

作者： Gao, Zilong;Li, Xiang;Jiang, Yiqing;Lu, Beihui;Zhang, Guozheng;Li, Yurong;Zhang, Yeshun;Zhang, Guozheng;Li, Yurong;Zhang, Yeshun;Huang, Wengong

作者机构：

期刊名称：BIOMACROMOLECULES （ 影响因子：5.4； 五年影响因子：5.8 ）

ISSN： 1525-7797

年卷期： 2025 年 26 卷 9 期

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收录情况： SCI

摘要： Bacterial infection and oxidative stress are major hindrances to wound healing. Designing bioactive wound dressings with inherent antibacterial and antioxidant activities is highly desirable. Herein, a novel multifunctional hydrogel was synthesized via a Schiff-base reaction between the amino groups of sericin and the aldehyde moieties of 2,3,4-trihydroxybenzaldehyde (THBA). The resulting hydrogel exhibited stable mechanical strength, exceptional tissue adhesiveness, and good biocompatibility, along with porous structures, a high swelling ratio, suitable gelation time, and adjustable degradability. In vitro experiments confirmed its inherent antibacterial and antioxidant capabilities, while in vivo studies using a full-thickness skin wound model in mice revealed accelerated wound healing and enhanced collagen deposition. These findings collectively underscore the potential of the sericin/THBA (SeT) hydrogel as an advanced dressing for effective wound management.

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