The origin and evolution of sex chromosomes, revealed by sequencing of the Silene latifolia female genome

文献类型： 外文期刊

第一作者： Yue, Jingjing

作者： Yue, Jingjing;Zhang, Xingtan;Xie, Wangyang;Kan, Baolin;Ming, Ray;Krasovec, Marc;Filatov, Dmitry A.;Krasovec, Marc;Kazama, Yusuke;Zhang, Shencheng;Xu, Xiuming

作者机构：

期刊名称：CURRENT BIOLOGY （ 影响因子：9.2； 五年影响因子：11.0 ）

ISSN： 0960-9822

年卷期： 2023 年 33 卷 12 期

页码：

收录情况： SCI

摘要： White campion (Silene latifolia, Caryophyllaceae) was the first vascular plant where sex chromosomes were discovered. This species is a classic model for studies on plant sex chromosomes due to presence of large, clearly distinguishable X and Y chromosomes that originated de novo about 11 million years ago (mya), but lack of genomic resources for this relatively large genome (-2.8 Gb) remains a significant hurdle. Here we report S. latifolia female genome assembly integrated with sex-specific genetic maps of this species, focusing on sex chromosomes and their evolution. The analysis reveals a highly heterogeneous recombination landscape with strong reduction in recombination rate in the central parts of all chromosomes. Recombination on the X chromosome in female meiosis primarily occurs at the very ends, and over 85% of the X chromosome length is located in a massive (-330 Mb) gene-poor, rarely recombining pericentromeric region (Xpr). The results indicate that the non-recombining region on the Y chromosome (NRY) initially evolved in a relatively small (-15 Mb), actively recombining region at the end of the q-arm, possibly as a result of inversion on the nascent X chromosome. The NRY expanded about 6 mya via linkage between the Xpr and the sex determining region, which may have been caused by expanding pericentromeric recombination suppression on the X chromosome. These findings shed light on the origin of sex chromosomes in S. latifolia and yield genomic resources to assist ongoing and future investigations into sex chromosome evolution.

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