Genomic analysis reveals a KIT-related chromosomal translocation associated with the white coat phenotype in yak

文献类型： 外文期刊

第一作者： Zhang, Fengwei

作者： Zhang, Fengwei;Wang, Chong;Xu, Haiyue;Yue, Xiangpeng;Zhang, Fengwei;Xia, Xiaoting;Luo, Xiaoyu;Lei, Chuzhao;Chen, Ningbo;Li, Kaihui;Han, Jianlin;Lei, Chuzhao;Chen, Ningbo

作者机构：

关键词： chromosomal translocation; coat colour; introgression; KIT gene; Tianzhu white yak

期刊名称：JOURNAL OF ANIMAL BREEDING AND GENETICS （ 影响因子：2.6； 五年影响因子：2.4 ）

ISSN： 0931-2668

年卷期： 2023 年 140 卷 3 期

页码：

收录情况： SCI

摘要： White coat pigmentation is a striking phenotype of many domesticated species and has various genetic controls. The Tianzhu White yak, an indigenous breed with a complete white coat, has fascinated Tibetans for centuries. However, the genetic basis of this trait remains unknown. Here, we conducted population genomics analysis and genome-wide association study based on the whole-genome sequencing data of 38 white and 59 non-white-coated yak. The results revealed the presence of KIT-linked Cs alleles characterized by the translocations between chromosomes 6 and 29 in all-white yak. Furthermore, structural variations showed additional duplications of the Cs alleles in white yak compared with colour-sidedness cattle. Interestingly, the Cs alleles associated with the white coat phenotype in yak were found to have introgressed from taurine cattle. Our findings unveil the shared genetic control of the white coat phenotype and its evolution in closely related bovine species.

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