Structurally diverse steroids from an endophyte of Aspergillus tennesseensis 1022LEF attenuates LPS-induced inflammatory response through the cholinergic anti-inflammatory pathway

文献类型： 外文期刊

第一作者： Su, Jun-Cheng

作者： Su, Jun-Cheng;Xu, Xingyuan;Lei, Xueping;Lei, Xueping;Lei, Xueping;Zhang, Peng;Wei, Xia

作者机构：

关键词： Steroids; Acetylcholinesterase; Inflammation; The cholinergic anti-inflammatory pathway

期刊名称：CHEMICO-BIOLOGICAL INTERACTIONS （ 影响因子：5.168； 五年影响因子：4.924 ）

ISSN： 0009-2797

年卷期： 2022 年 362 卷

页码：

收录情况： SCI

摘要： The emerging cholinergic anti-inflammatory pathway plays a key role in regulating inflammation. Steroids are known to possess remarkable anti-inflammatory activity. However, the links between steroids and the cholinergic anti-inflammatory pathway remain unidentified. In this study, eight steroids (1-8) featuring five different structural types were characterized from an endophytic fungus Aspergillus tennesseensis 1022LEF, and were subsequently evaluated for their potential role in regulating the cholinergic anti-inflammatory pathway. As a result, compound 8, with the best potency, showed remarkable anti-inflammatory activity at the nanomolar to low micromolar level. Further pharmacological study indicated that 8 notably increased alpha 7nAchR expression and inhibited the activation of its down-stream signaling pathways. Collectively, the present study not only highlighted the potential correlation between steroids and the cholinergic anti-inflammatory pathway, but also identified 8 as a dual-functional modulator via directly inhibition to acetylcholinesterase as well as up-regulation of alpha 7nAchR expression.

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