Parthenogenetic Haemaphysalis longicornis acetylcholinesterases are triggered by the repellent effect of cinnamaldehyde, a primary compound found in cinnamon oil

文献类型： 外文期刊

第一作者： Kuang, Ceyan

作者： Kuang, Ceyan;Cao, Jie;Zhou, Yongzhi;Zhang, Houshuang;Wang, Yanan;Zhou, Jinlin

作者机构：

关键词： Tick; Repellent; Acetylcholinesterase; Transcriptome; Metabolome; Electroantennography

期刊名称：TICKS AND TICK-BORNE DISEASES （ 影响因子：3.4； 五年影响因子：3.2 ）

ISSN： 1877-959X

年卷期： 2024 年 15 卷 6 期

页码：

收录情况： SCI

摘要： The control and prevention of ticks and tick-borne diseases rely on chemical insecticides and repellents. Plantderived compounds potentially represent new and safer repellents. Cinnamaldehyde, a component of cinnamon oil, exhibits antibacterial, anti-inflammatory, acaricidal, and repellent activity against ticks. Here we studied the molecular mechanism of the repellent effect of cinnamaldehyde on Haemaphysalis longicornis. A 2 % cinnamaldehyde treatment resulted in >90 % nymph repellency within 6 h. Nymphs were exposed to cinnamaldehyde for 30 min, and subsequent transcriptome and metabolome analyses revealed the involvement of H. longicornis Acetylcholinesterases (HL-AchEs) in the response process. HL-AchEs was transcribed in all tick developmental stages and tissues. Following cinnamaldehyde treatment, the transcript and specific activity of the enzyme of AchE were significantly altered. Following RNAi, electroantennography (EAG) tests demonstrated a significant decrease in response to various repellents as well as a significant decrease in repellency. Our findings have revealed that HL-AchEs mediates cinnamaldehyde-induced tick repellency, and the results provide insights into the mechanism of plant-derived tick repellents.

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