Molecular targets and their application examples for interrupting chitin biosynthesis

文献类型： 外文期刊

第一作者： Duan, Yanwei

作者： Duan, Yanwei;Yang, Qing;Duan, Yanwei;Yang, Qing

作者机构：

关键词： Chitin biosynthesis; Chitin deacetylase; Chitinase; Hexosaminidase; Pesticide; Fungicide

期刊名称：CHINESE CHEMICAL LETTERS （ 影响因子：8.9； 五年影响因子：7.3 ）

ISSN： 1001-8417

年卷期： 2025 年 36 卷 4 期

页码：

收录情况： SCI

摘要： Chitin is an abundant aminopolysaccharide found in insect pests and phytopathogenic microorganisms but absent in higher plants and vertebrates. It is crucial for mitigating threats posed by chitin-containing organisms to human health, food safety, and agriculture. Therefore, targeting the chitin biosynthesis- associated bioprocess holds a promise for developing human-safe and eco-friendly antifungal agents or pesticides. Chitin biosynthesis requires chitin synthase and associated factors, which are involved in the modification, regulation, organization or turnover of chitin during its biosynthesis. A number of enzymes such as chitinases, hexosaminidases, chitin deacetylases are closely related and therefore are promising targets for designing novel agrochemicals that target at chitin biosynthesis. This review summarizes the advances in understanding chitin biology over the past decade by our research group and collaborates, specifically regarding essential proteins linked to chitin biosynthesis that can be exploited as promising pesticide targets. Examples of small bioactive molecules that against the activity of these targets are given. (c) 2025 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.

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