Multi-omics analysis of the protective effects of Platycodon grandiflorum-derived inulin-type fructan against low-concentration PM2.5-induced lung microenvironment changes in rats

文献类型： 外文期刊

第一作者： Xiong, Yi

作者： Xiong, Yi;Lu, Weihong;Xiong, Yi;Lu, Weihong;Fu, Xinjing;Zhao, Wenjie;Han, Yunlin;Xu, Yanfeng;Qu, Yajin;Sun, Xiuping;Guo, Jianguo;Shan, Shan;Lu, Shuwen

作者机构：

关键词： Platycodon grandiflorum; PM2.5 inhalation exposure; Inulin-type fructans; Protective mechanism

期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：8.5； 五年影响因子：8.7 ）

ISSN： 0141-8130

年卷期： 2025 年 310 卷

页码：

收录情况： SCI

摘要： In northern China, haze events frequently occur during winter, and PM2.5 is recognized as the most significant particulate matter in haze, posing a major threat to human health. Therefore, we employed a PM2.5 inhalation exposure system to investigate the protective effects of Platycodon grandiflorum inulin-type fructan (PGPI-1-a) on low-concentration PM2.5-induced lung microenvironment changes. Our findings revealed that long-term (4month) PM2.5 exposure did not cause apparent pathological alterations in rat lungs but induced lung inflammation, which was alleviated by PGPI-1-a intervention. Multi-omics analysis demonstrated that PGPI-1-a restored abnormally expressed lung proteins, improved lung microbiota disorders, and regulated serum metabolite imbalances related to lipid and amino acid metabolism, ameliorating low-concentration PM2.5induced lung microenvironment changes. These results suggest that Platycodon grandiflorum inulin-type fructan could serve as a potential dietary supplement for mitigating PM2.5-induced lung injury.

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