Post-Translational Modifications in Mammalian Folliculogenesis and Ovarian Pathologies

文献类型： 外文期刊

第一作者： Chen, Dake

作者： Chen, Dake;Feng, Yue;Wu, Junjing;Zhou, Jiawei;Li, Zipeng;Qiao, Mu;Chen, Tong;Xu, Zhong;Peng, Xianwen;Mei, Shuqi

作者机构：

关键词： post-translational modification; follicular development; polycystic ovary syndrome; premature ovarian insufficiency

期刊名称：CELLS （ 影响因子：5.2； 五年影响因子：6.1 ）

ISSN：

年卷期： 2025 年 14 卷 16 期

页码：

收录情况： SCI

摘要： Post-translational modifications (PTMs) of proteins, as the core mechanism for dynamically regulating follicular development, affect the maintenance of mammalian fertility by precisely coordinating granulosa cell-oocyte interaction, metabolic reprogramming, and epigenetic remodeling. Dysregulation of these modifications directly contributes to major reproductive diseases, including polycystic ovary syndrome (PCOS) and premature ovarian insufficiency (POI). Post-translational modifications regulate follicular development through intricate mechanisms. Thus, this review systematically synthesizes recent advances in PTMs, encompassing traditional ones such as phosphorylation, ubiquitination, and acetylation, alongside emerging modifications including lactylation, SUMOylation, and ISGylation, thereby constructing a more comprehensive PTM landscape of follicular development. Furthermore, this study dissects the molecular interaction networks of these PTMs during follicular activation, maturation, and ovulation, and uncovers the common mechanisms through which PTM dysregulation contributes to pathological conditions, including hyperandrogenism in PCOS and follicular depletion in POI. Finally, this review ultimately provides a theoretical basis for improving livestock reproductive efficiency and precise intervention in clinical ovarian diseases.

分类号：

  • 相关文献
作者其他论文 更多>>
  • Valuing the Ecological Products of Wetlands and Strategies for Implementation: A Case Study of Weishui Wetland in Songzi City, Hubei Province

    作者：Deng, Haoyu;Li, Chengmin;Song, Yulan;Cao, Jian;Chen, Tong

    关键词：ecological product value; GEP accounting; choice of experiment (CE) method; realization pathway

  • An inactivated influenza D virus vaccine protects guinea pigs from infections and contact transmission caused by homologous challenge

    作者：Dong, Zhipeng;Gao, Hongbo;Wang, Tiecheng;Xia, Xianzhu;Sun, Weiyang;Gao, Yuwei;Dong, Zhipeng;Lu, Pengyang;Wang, Tiecheng;Xia, Xianzhu;Feng, Yue;Wan, Wentao

    关键词：Influenza D virus; Inactivated vaccine; Contact transmission; Guinea pigs

  • Integrating large-scale meta-GWAS and PigGTEx resources to decipher the genetic basis of 232 complex traits in pigs

    作者：Xu, Zhiting;Lin, Qing;Cai, Xiaodian;Zhong, Zhanming;Teng, Jinyan;Zeng, Haonan;Gao, Yahui;Wei, Chen;Zhou, Jun;Zhang, Wenjing;Zhang, Xiaoke;Shi, Shaolei;Wu, Jun;Diao, Shuqi;Liu, Yuqiang;Pan, Xiangchun;Feng, Xueyan;Liu, Ruiqi;Su, Zhanqin;Chang, Chengjie;Zhu, Qianghui;Wu, Yuwei;Zhang, Hao;Yuan, Xiaolong;Li, Jiaqi;Zhang, Zhe;Li, Bingjie;Gao, Yahui;Liu, George E.;Gao, Yahui;Ma, Li;Cai, Zexi;Bai, Zhonghao;Su, Guosheng;Sahana, Goutam;Lund, Mogens Sando;Fang, Lingzhao;Wang, Xiaoqing;Shi, Liangyu;Zhao, Fuping;Wang, Xue;Wang, Yi;Zhang, Zipeng;Ding, Xiangdong;Lin, Yu;Tang, Guoqing;Li, Mingzhou;Li, Xuewei;Liu, Shuli;Yin, Hongwei;Bai, Lijing;Li, Kui;Zhou, Zhongyin;Wang, Qishan;Pan, Yuchun;Xu, Zhong;Peng, Xianwen;Mei, Shuqi;Mo, Delin;Liu, Xiaohong;Chen, Yaosheng;Liu, Yang;Xiang, Ruidong;Xiang, Ruidong;Shen, Xia;Shen, Xia;Shen, Xia;Li, Pinghua;Huang, Ruihua;Li, Pinghua;Huang, Ruihua;Ballester, Maria;Crespo-Piazuelo, Daniel;Amills, Marcel;Clop, Alex;Amills, Marcel;Karlskov-Mortensen, Peter;Fredholm, Merete;Zhang, Qin;Zhao, Yunxiang

    关键词：pig; meta-GWAS; PigGTEx; molQTL; complex traits

  • EasyMetagenome: A user-friendly and flexible pipeline for shotgun metagenomic analysis in microbiome research

    作者：Bai, Defeng;Xun, Jiani;Ma, Chuang;Luo, Hao;Yang, Haifei;Hou, Huiyu;Lv, Hujie;Wan, Xiulin;Wang, Yao;Yousuf, Salsabeel;Zeng, Meiyin;Zhang, Tianyuan;Gao, Yunyun;Liu, Yong-Xin;Chen, Tong;Ma, Chuang;Yang, Haifei;Cao, Chen;Cao, Xiaofeng;Cui, Jianzhou;Deng, Yuan-Ping;Deng, Zhaochao;Yu, Hao;Zhang, Chunfang;Dong, Wenxin;Dong, Wenxue;Du, Juan;Fang, Qunkai;Fang, Wei;Fang, Yue;Luan, Yaning;Fu, Fangtian;Fu, Min;Fu, Yi-Tian;Gao, He;Ge, Jingping;Guo, Yuhao;Gong, Qinglong;Lou, Wenbo;Gu, Lunda;Yang, Li;Guo, Peng;Hai, Tang;Liu, Hao;He, Jieqiang;He, Zi-Yang;Huang, Can;Ji, Shuai;Jiang, ChangHai;Jiang, Gui-Lai;Jiang, Lingjuan;Jin, Ling N.;Li, Changchao;Kan, Yuhe;Kang, Da;Kou, Jin;Lam, Ka-Lung;Li, Chong;Li, Fuyi;Li, Liwei;Li, Miao;Li, Xin;Li, Ye;Li, Zheng-Tao;Zhu, Chengshuai;Liang, Jing;Mo, Jiayuan;Lin, Yongxin;Liu, Changzhen;Liu, Danni;Zhang, Jing;Chen, Shifu;Liu, Fengqin;Liu, Jia;Liu, Tianrui;Liu, Tingting;Wang, Xinlong;Liu, Xinyuan;Luo, Yuanyuan;Liu, Yaqun;Liu, Bangyan;Liu, Minghao;Lv, Hujie;Ma, Tengfei;Mai, Zongjiong;Niu, Dongze;Pan, Zhuo;Qi, Heyuan;Shi, Zhanyao;Song, Chunjiao;Sun, Fuxiang;Sun, Yan;Tian, Sihui;Wang, Guoliang;Wang, Hongyang;Wang, Hongyu;Wang, Huanhuan;Wang, Jing;Wang, Jun;Wang, Kang;Wang, Leli;Yao, Xiaofang;Wang, Shao-kun;Xiao, Zufei;Xing, Huichun;Xu, Yifan;Yang, Song;Yan, Shu-yan;Zhang, Yi-Bo;Yang, Yuanming;Lei, Yu;Yuan, Zhengrong;Zhang, Chunge;Zhang, Huimin;Zhang, Na;Zhang, Yupeng;Zhang, Zheng;Zhou, Mingda;Zhou, Yuanping;Zhu, Zhihao;Zhu, Lin;Zhu, Yue;Zou, Hongqin;Zuo, Anna;Dong, Wenxuan;Wen, Tao;Chen, Shifu;Chen, Shifu;Li, Guoliang

    关键词：metagenome; microbiome; microbiota; pipeline; visualization

  • An R2R3-type MYB transcription factor, GmMYB77, negatively regulates isoflavone accumulation in soybean [Glycine max (L.) Merr.]

    作者：Liu, Yitian;Zhang, Shengrui;Li, Jing;Muhammad, Azam;Feng, Yue;Qi, Jie;Sha, Dan;Hao, Yushui;Li, Bin;Sun, Junming

    关键词：soybean; malonylglycitin; total isoflavone; GmMYB77; haplotype

  • High resolution QTL mapping and candidate gene mining for seed oil content and fatty acid composition in soybean

    作者：Zhang, Shibi;Feng, Huoyi;Zhang, Shengrui;Qi, Jie;Feng, Yue;Li, Yecheng;Ma, Caiyou;Liu, Yitian;Azam, Muhammad;Li, Jing;Sun, Junming;Li, Bin;Agyenim-Boateng, Kwadwo Gyapong;Gu, Yongzhe;Qiu, Lijuan;Feng, Yue

    关键词：Soybean (Glycine max L.); Oil; Fatty acid; QTL mapping; Candidate gene; Haplotype

  • Suppression of ergosterol biosynthesis by dictamnine confers resistance to gray mold on harvested fruit

    作者：Liu, Kui;Liu, Yuhan;Liu, Yangzhi;Huang, Xinhua;Tian, Shiping;Chen, Tong;Liu, Kui;Liu, Yuhan;Liu, Yangzhi;Huang, Xinhua;Tian, Shiping;Chen, Tong;Liu, Kui;Liu, Yuhan;Liu, Yangzhi;Huang, Xinhua;Tian, Shiping;Jia, Yanhong;Ji, Lizhu

    关键词：Antifungal; Botrytis cinerea; Ergosterol biosynthesis; Fruit; Postharvest; Transcriptome analysis

微信小程序