Post-Translational Modifications in Mammalian Folliculogenesis and Ovarian Pathologies

文献类型： 外文期刊

第一作者： Chen, Dake

作者： Chen, Dake;Feng, Yue;Wu, Junjing;Zhou, Jiawei;Li, Zipeng;Qiao, Mu;Chen, Tong;Xu, Zhong;Peng, Xianwen;Mei, Shuqi

作者机构：

关键词： post-translational modification; follicular development; polycystic ovary syndrome; premature ovarian insufficiency

期刊名称：CELLS （ 影响因子：5.2； 五年影响因子：6.1 ）

ISSN：

年卷期： 2025 年 14 卷 16 期

页码：

收录情况： SCI

摘要： Post-translational modifications (PTMs) of proteins, as the core mechanism for dynamically regulating follicular development, affect the maintenance of mammalian fertility by precisely coordinating granulosa cell-oocyte interaction, metabolic reprogramming, and epigenetic remodeling. Dysregulation of these modifications directly contributes to major reproductive diseases, including polycystic ovary syndrome (PCOS) and premature ovarian insufficiency (POI). Post-translational modifications regulate follicular development through intricate mechanisms. Thus, this review systematically synthesizes recent advances in PTMs, encompassing traditional ones such as phosphorylation, ubiquitination, and acetylation, alongside emerging modifications including lactylation, SUMOylation, and ISGylation, thereby constructing a more comprehensive PTM landscape of follicular development. Furthermore, this study dissects the molecular interaction networks of these PTMs during follicular activation, maturation, and ovulation, and uncovers the common mechanisms through which PTM dysregulation contributes to pathological conditions, including hyperandrogenism in PCOS and follicular depletion in POI. Finally, this review ultimately provides a theoretical basis for improving livestock reproductive efficiency and precise intervention in clinical ovarian diseases.

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