ATG4B hinders porcine epidemic diarrhea virus replication through interacting with TRAF3 and activating type-I IFN signaling
文献类型： 外文期刊
第一作者： Dong, Sujie
作者： Dong, Sujie;Li, Youwen;Dong, Sujie;Kong, Ning;Qin, Wenzhen;Zhai, Huanjie;Zhai, Xueying;Yang, Xinyu;Ye, Chenqian;Ye, Manqing;Liu, Changlong;Yu, Lingxue;Zheng, Hao;Tong, Wu;Yu, Hai;Tong, Guangzhi;Shan, Tongling;Zhang, Wen
作者机构：
关键词： ATG4B; PEDV; TRAF3; IFN; Replication
期刊名称：VETERINARY MICROBIOLOGY （ 影响因子：3.246； 五年影响因子：3.565 ）
ISSN： 0378-1135
年卷期： 2022 年 273 卷
页码：
收录情况： SCI
摘要： Autophagy-related 4B (ATG4B) is found to exert a vital function in viral replication, although the mechanism through which ATG4B activates type-I IFN signaling to hinder viral replication remains to be explained, so far. The current work revealed that ATG4B was downregulated in porcine epidemic diarrhea virus (PEDV)-infected LLC-PK1 cells. In addition, ATG4B overexpression inhibited PEDV replication in both Vero cells and LLC-PK1 cells. On the contrary, ATG4B knockdown facilitated PEDV replication. Moreover, ATG4B was observed to hinder PEDV replication by activating type-I IFN signaling. Further detailed analysis revealed that the ATG4B protein targeted and upregulated the TRAF3 protein to induce IFN expression via the TRAF3-pTBK1-pIRF3 pathway. The above data revealed a novel mechanism underlying the ATG4B-mediated viral restriction, thereby providing novel possibilities for preventing and controlling PEDV.
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