ATG4B hinders porcine epidemic diarrhea virus replication through interacting with TRAF3 and activating type-I IFN signaling
文献类型： 外文期刊
第一作者： Dong, Sujie
作者： Dong, Sujie;Li, Youwen;Dong, Sujie;Kong, Ning;Qin, Wenzhen;Zhai, Huanjie;Zhai, Xueying;Yang, Xinyu;Ye, Chenqian;Ye, Manqing;Liu, Changlong;Yu, Lingxue;Zheng, Hao;Tong, Wu;Yu, Hai;Tong, Guangzhi;Shan, Tongling;Zhang, Wen
作者机构：
关键词： ATG4B; PEDV; TRAF3; IFN; Replication
期刊名称：VETERINARY MICROBIOLOGY （ 影响因子：3.246； 五年影响因子：3.565 ）
ISSN： 0378-1135
年卷期： 2022 年 273 卷
页码：
收录情况： SCI
摘要： Autophagy-related 4B (ATG4B) is found to exert a vital function in viral replication, although the mechanism through which ATG4B activates type-I IFN signaling to hinder viral replication remains to be explained, so far. The current work revealed that ATG4B was downregulated in porcine epidemic diarrhea virus (PEDV)-infected LLC-PK1 cells. In addition, ATG4B overexpression inhibited PEDV replication in both Vero cells and LLC-PK1 cells. On the contrary, ATG4B knockdown facilitated PEDV replication. Moreover, ATG4B was observed to hinder PEDV replication by activating type-I IFN signaling. Further detailed analysis revealed that the ATG4B protein targeted and upregulated the TRAF3 protein to induce IFN expression via the TRAF3-pTBK1-pIRF3 pathway. The above data revealed a novel mechanism underlying the ATG4B-mediated viral restriction, thereby providing novel possibilities for preventing and controlling PEDV.
分类号：
- 相关文献
作者其他论文 更多>>
-
Development of an enhanced hybrid attention YOLOv8s small object detection method for phenotypic analysis of root nodules
作者：Zhao, Ya;Zhang, Wen;Zhang, Liangxiao;Tang, Xiaoqian;Wang, Du;Zhang, Qi;Li, Peiwu;Tang, Xiaoqian;Zhang, Qi;Li, Peiwu;Zhao, Ya;Li, Peiwu
关键词：Root nodules; YOLOv8s; Hybrid attention mechanism; Small object detection; Phenotypic characteristics
-
Engineering a live-attenuated porcine reproductive and respiratory syndrome virus vaccine to prevent RNA recombination by rewiring transcriptional regulatory sequences
作者：Li, Liwei;Chen, Jinxia;Cao, Zhengda;Guo, Ziqiang;Liu, Jiachen;Zhou, Yanjun;Tong, Guangzhi;Gao, Fei;Chen, Jinxia;Tong, Guangzhi;Gao, Fei
关键词：RNA recombination; porcine reproductive and respiratory syndrome virus (PRRSV); transcriptional regulatory sequence (TRS); recombination-resistant; vaccine redesign
-
Variation in microbial communities and network ecological clusters driven by soil organic carbon in an inshore saline soil amended with hydrochar in Yellow River Delta, China
作者：Yao, Hui;Cheng, Yadong;Kong, Qingxian;Wang, Xiao;You, Xiangwei;Li, Yiqiang;Yao, Hui;Cheng, Yadong;Wang, Xiao;You, Xiangwei;Li, Yiqiang;Rong, Ziguo;Quan, Yue;Zheng, Hao
关键词：Soil carbon; Hydrochar; Soil microorganism; Ecological cluster; Coastal salt-affected soil; Soil health
-
Japanese encephalitis virus NS3 captures the protein translation element by interacting with HNRNPH1 to promote viral replication
作者：Wang, Xingya;Li, Lin;Liu, Xuelan;Wang, Xingya;Kong, Ning;Wang, Chen;Qin, Wenzhen;Yang, Xinyu;Yu, Hai;Tong, Wu;Tong, Guangzhi;Zheng, Hao;Shan, Tongling;Kong, Ning;Yu, Hai;Tong, Wu;Tong, Guangzhi;Zheng, Hao;Shan, Tongling;Liu, Xuelan
关键词：JEV; NS3; HNRNPH1; Translation regulation element
-
Partial replacement by ammonium nutrition enhances Brassica napus growth by promoting root development, photosynthesis, and nitrogen metabolism
作者：Zhang, Wen;Munyaneza, Venuste;Wang, Dandan;Huang, Chenfeng;Wu, Siyuan;Han, Mingcun;Ding, Guangda;Wang, Xu;Kant, Surya
关键词：Brassica napus; Ammonium; Nitrate; Photosynthesis; Nitrogen metabolism
-
Phthalates esters disrupt demersal fish behavior: Unveiling the brain-gut axis impact
作者：Liu, Liuqingqing;Li, Xinyao;Luo, Xianxiang;Liu, Linjia;Yuan, Zixi;Sun, Cuizhu;Zheng, Hao;Li, Fengmin;Luo, Xianxiang;Zheng, Hao;Li, Fengmin;Wang, Xiao;Xu, Elvis Genbo
关键词：Endocrine disrupting chemicals; Neurotoxicity; Brain-gut axis; Anxiety behavior; Gut microbiome; Behavioral ecology
-
Salmonella Typhimurium persistently infects host via its effector SseJ-induced PHB2-mediated mitophagy
作者：Sun, Dage;Li, Jiayi;Dai, Changzhi;Chen, Kaifeng;Wang, Yu;Pan, Peng;Zhu, Ting;Xu, Chenggang;Liao, Ming;Zhang, Jianmin;Gou, Hongchao;Shen, Haiyan;Zhang, Yu;Shan, Tongling;Liao, Ming
关键词：Mitophagy; PHB2; PINK1; PRKN;
Salmonella Typhimurium; SseJ
