Bidirectional "Win-Win": Asymmetrical Nanobowl-Coupled Aggregation-Induced Emissive Nanosilicon-Enhanced Immunochromatographic Strips for the Ultrasensitive Detection of Salmonella typhimurium

文献类型： 外文期刊

第一作者： Li, Yuechun

作者： Li, Yuechun;Zhang, Wenrui;Wang, Ziqi;Cui, Zhaowen;Shi, Longhua;Wang, Jianlong;Bu, Tong;Sun, Jing;Cheng, Jie;Yang, Qingyu

作者机构：

期刊名称：ANALYTICAL CHEMISTRY （ 影响因子：6.7； 五年影响因子：6.6 ）

ISSN： 0003-2700

年卷期： 2024 年 96 卷 45 期

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收录情况： SCI

摘要： The lack of nanoprobes with an efficient signal response and overlook of cooperation between nanoprobes can be responsible for the unsatisfactory analytical performance of immunochromatographic strips (ITSs). Herein, asymmetrical nanobowl-confined innumerable gold nanoparticles (AuNPs) (AuNPs@AFRNBs) to enhance the light absorption are developed for quenching the fluorescence of aggregation-induced emissive (AIE) nanosilicons, which is used for the construction of a bidirectional complementary-enhanced ITS (BC-ITS) to ultrasensitively detect Salmonella typhimurium (S. typhimurium). Briefly, density functional theory-screened AIEgens with highly fluorescent brightness are confined in nanosilicons, and the nanoconfinement has improved the fluorescent brightness by 6.78-fold compared to the free AIEgens. Moreover, the substituent group effect has also enhanced the fluorescence of the prepared fluorescent nanosilicon by 10,000-fold in ITSs. By virtue of the superior light absorption of AuNPs@AFRNBs, the BC-ITS exhibits a bidirectional "win-win" performance for the sensitive monitoring of S. typhimurium: a "turn-on" mode with a high-brightness colorimetric response and an inverse "turn-off" fluorescence response, whose limits of detection are 364 and 302 CFU mL-1, respectively, which is approximately 100-fold more sensitive than the traditional AuNPs-ITS. Furthermore, the BC-ITS can be successfully used to identify S. typhimurium in milk, illustrating the superiority of the developed BC-ITS in point-of-care diagnosis.

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