Gut microbiota modulation and anti-inflammatory properties of anthocyanins from the fruits of Lycium ruthenicum Murray in dextran sodium sulfate-induced colitis in mice

文献类型： 外文期刊

第一作者： Peng, Yujia

作者： Peng, Yujia;Wan, Peng;Chen, Dan;Ding, Yu;Zeng, Xiaoxiong;Yan, Yamei;Mi, Jia;Lu, Lu;Zhang, Zhijuan;Li, Xiaoying;Cao, Youlong;Ran, Linwu

作者机构：

关键词： Lycium ruthenicum Murray; Anthocyanins; Inflammatory bowel disease; Dextran sodium sulfate; Gut microbiota

期刊名称：FREE RADICAL BIOLOGY AND MEDICINE （ 影响因子：8.101； 五年影响因子：8.176 ）

ISSN： 0891-5849

年卷期： 2019 年 136 卷

页码：

收录情况： SCI

摘要： In the present study, the therapeutic effects of crude anthocyanins (ACN) from the fruits of Lycium ruthenicum Murray and the main monomer of ACN, petunidin 3-O-[rhamnopyranosyl-(trans-p-coumaroyl)]-5-O-[beta-D-glucopyranoside] (P3G), on the dextran sodium sulfate (DSS)-induced colitis in mice were investigated. Both ACN and P3G showed intestinal anti-inflammatory effects, evidenced by restoration of various physical signs (body weight, feed quantity, solid fecal weight and colon length were increased, and DAI score was decreased), reduction of the expression of proinflammatory cytokines and related mRNA (such as TNF-alpha, IL-6, IL-1 beta and IFN-gamma), and promotion of the intestinal barrier function by histological and immunofluorescence analysis (proteins such as ZO-1, occludin and claudin-1 were increased). Furthermore, the effects on gut microbiota community of DSS-induced colitis in mice have been investigated. It was found that Porphyromonadaceae, Helicobacter, Parasutterella, Parabacteroides, Oscillibacter and Lachnospiraceae were the key bacteria associated with inflammatory bowel disease. Taken together, P3G and ACN ameliorated DSS-induced colitis in mice through three aspects including blocking proinflammatory cytokines, increasing tight junction protein and modulating gut microbiota. What's more, P3G showed better anti-inflammatory effects than ACN.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序