Integration of Transcriptomic and Metabolomic Profiles Provides Insights into the Influence of Nitrogen on Secondary Metabolism in Fusarium sacchari

文献类型： 外文期刊

第一作者： Bao, Yixue

作者： Bao, Yixue;Lin, Zhenyue;Yao, Wei;Akbar, Sehrish;Lin, Wenfeng;Zhang, Muqing;Bao, Yixue;Lin, Zhenyue;Yao, Wei;Akbar, Sehrish;Lin, Wenfeng;Zhang, Muqing;Bao, Yixue;Lin, Zhenyue;Yao, Wei;Akbar, Sehrish;Lin, Wenfeng;Zhang, Muqing;Powell, Charles A.;Zhang, Muqing;Xu, Jianlong;Bao, Yixue;Xu, Jianlong;Lin, Zhenyue

作者机构：

关键词： nitrogen; secondary metabolism; Fusarium sacchari; gibberellin; mycotoxin

期刊名称：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES （ 影响因子：5.6； 五年影响因子：6.2 ）

ISSN： 1661-6596

年卷期： 2023 年 24 卷 13 期

页码：

收录情况： SCI

摘要： Nitrogen availability might play an essential role in plant diseases by enhancing fungal cell growth and influencing the expression of genes required for successful pathogenesis. Nitrogen availability could modulate secondary metabolic pathways as evidenced by the significant differential expression of several core genes involved in mycotoxin biosynthesis and genes encoding polyketide synthase/nonribosomal peptide synthetases, cytochrome P450 and carbohydrate-active enzymes in Fusarium sacchari, grown on different nitrogen sources. A combined analysis was carried out on the transcript and metabolite profiles of regulatory metabolic processes and the virulence of Fusarium sacchari grown on various nitrogen sources. The nitrogen regulation of the gibberellin gene cluster included the metabolic flux and multiple steps of gibberellin synthesis. UHPLC-MS/MS-based metabolome analysis revealed the coordination of these related transcripts and the accumulation of gibberellin metabolites. This integrated analysis allowed us to uncover additional information for a more comprehensive understanding of biological events relevant to fungal secondary metabolic regulation in response to nitrogen availability.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序