Role of domestic ducks in the propagation and biological evolution of highly pathogenic H5N1 influenza viruses in Asia

文献类型： 外文期刊

第一作者： Hulse-Post, DJ

作者： Hulse-Post, DJ;Sturm-Ramirez, KM;Humberd, J;Seiler, P;Govorkova, EA;Krauss, S;Scholtissek, C;Puthavathana, P;Buranathai, C;Nguyen, TD;Long, HT;Naipospos, TSP;Chen, H;Ellis, TM;Guan, Y;Peiris, JSM;Webster, RG

作者机构：

关键词： avian influenza;pathogenicity

期刊名称：PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA （ 影响因子：11.205； 五年影响因子：12.291 ）

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收录情况： SCI

摘要： Wild waterfowl, including ducks, are natural hosts of influenza A viruses. These viruses rarely caused disease in ducks until 2002, when some H5N1 strains became highly pathogenic. Here we show that these H5N1 viruses are reverting to nonpathogenicity in ducks. Ducks experimentally infected with viruses isolated between 2003 and 2004 shed virus for an extended time (up to 17 days), during which variant viruses with low pathogenicity were selected. These results suggest that the duck has become the "Trojan horse" of Asian H5N1 influenza viruses. The ducks that are unaffected by infection with these viruses continue to circulate these viruses, presenting a pandemic threat.

分类号： N

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