文献类型： 外文期刊
第一作者： Ji, Jingwen
作者： Ji, Jingwen;Iqbal, Zafar;Sun, Jian;Zhou, Pengjuan;Zhai, Lijuan;He, Lili;Tang, Dong;Ji, Jinbo;Yang, Haikang;Yang, Zhixiang;Li, Liuyan
作者机构：
关键词： N1-caffeoyl-N10-dihydrocaffeoylspermidine; spermidine; alkaloid; yields; medicinally valuable; natural compound; synthesis
期刊名称：LETTERS IN ORGANIC CHEMISTRY （ 影响因子：0.8； 五年影响因子：0.7 ）
ISSN： 1570-1786
年卷期： 2024 年 21 卷 8 期
页码：
收录情况： SCI
摘要： N1-caffeoyl-N10-dihydrocaffeoylspermidine (Scotanamine D), a spermidine alkaloid isolated from various plants, is a medicinally valuable natural product. Recent studies have pointed out several health benefits of this compound. However, its synthetic procedures are still not described in the literature. We report the synthesis of this compound following two different schemes comprising multiple steps with excellent overall yields, which are 57% and 81%, respectively. These two synthetic schemes, which use commercially available and cheaper starting materials, can facilitate the large-scale manufacturing of Scotanamine D.
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