Lipopeptide C17 Fengycin B Exhibits a Novel Antifungal Mechanism by Triggering Metacaspase-Dependent Apoptosis in Fusarium oxysporum

文献类型： 外文期刊

第一作者： Deng, Ying-jie

作者： Deng, Ying-jie;Chen, Yan-ping;Wang, Jie-ping;Xiao, Rong-feng;Liu, Bo;Chen, Mei-chun;Deng, Ying-jie;Wang, Xun;He, Jin;Deng, Ying-jie;Wang, Xun;He, Jin;Chen, Zheng

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关键词： Bacillus; lipopeptide; fengycin; pathogenic fungus; Fusarium oxysporum; cellapoptosis; metacaspase-dependent

期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：6.1； 五年影响因子：6.3 ）

ISSN： 0021-8561

年卷期： 2024 年 72 卷 14 期

页码：

收录情况： SCI

摘要： Fusarium wilt is a worldwide soil-borne fungal disease caused by Fusarium oxysporum that causes serious damage to agricultural products. Therefore, preventing and treating fusarium wilt is of great significance. In this study, we purified ten single lipopeptide fengycin components from Bacillus subtilis FAJT-4 and found that C-17 fengycin B inhibited the growth of F. oxysporum FJAT-31362. We observed early apoptosis hallmarks, including reactive oxygen species accumulation, mitochondrial dysfunction, and phosphatidylserine externalization in C-17 fengycin B-treated F. oxysporum cells. Further data showed that C-17 fengycin B induces cell apoptosis in a metacaspase-dependent manner. Importantly, we found that the expression of autophagy-related genes in the TOR signaling pathway was significantly upregulated; simultaneously, the accumulation of acidic autophagy vacuoles in F. oxysporum cell indicated that the autophagy pathway was activated during apoptosis induced by C-17 fengycin B. Therefore, this study provides new insights into the antifungal mechanism of fengycin.

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