Synthesis of the ternary nanocomposites composed of zinc 2-methylimidazolate frameworks, lactoferrin and melittin for antifungal therapy

文献类型： 外文期刊

第一作者： Yu, Dixiong

作者： Yu, Dixiong;Yu, Qilin;Liu, Shuo;Li, Mingchun;Wang, Yufan;Zhang, Jun;Liu, Shuo

作者机构：

期刊名称：JOURNAL OF MATERIALS SCIENCE （ 影响因子：4.682； 五年影响因子：4.128 ）

ISSN： 0022-2461

年卷期： 2022 年 57 卷 35 期

页码：

收录情况： SCI

摘要： Fungal infections caused by Candida albicans and related pathogenic fungi are threatening the health of millions of people worldwide. Natural antimicrobial peptides are promising candidates for antimicrobial therapy, but their application is compromised by their toxicity to mammalian cells. In this study, zeolitic imidazolate framework-8 nanosheets (ZM), the fungus-targeting lacto-ferrin (LFP), and the model antimicrobial peptide melittin (Mel) were co-assembled to form ternary nanocomposites by electrostatic interaction for treating pathogenic fungal infections. The results showed that the ternary nanocomposites ZM+LFP+Mel exhibited strong inhibitory activity against growth of the fungal pathogen C. albicans and had stronger capacity to eradicate fungal biofilms than free Mel. The in vivo mice wound model further showed that the nanocomposites had excellent anti-infection ability and drastically promoted wound healing. This study provides a facile strategy to detoxify antimicrobial peptides and to enhance its antimicrobial efficiency for biomedical application. [GRAPHICS] .

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