文献类型： 外文期刊
第一作者： Shang, Lu
作者： Shang, Lu;Chen, Chan;Sun, Rui;Guo, Juan;Liu, Jing;Wang, Mi;Zhang, Lifang;Fei, Chenzhong;Xue, Feiqun;Liu, Yingchun;Gu, Feng;Shang, Lu;Chen, Chan;Sun, Rui;Guo, Juan;Liu, Jing;Wang, Mi;Zhang, Lifang;Fei, Chenzhong;Xue, Feiqun;Liu, Yingchun;Gu, Feng
作者机构：
关键词： antibiotic resistance; multidrug-resistant pathogens; antimicrobial peptide; biosafety; biofilm
期刊名称：ACS APPLIED MATERIALS & INTERFACES （ 影响因子：9.5； 五年影响因子：9.6 ）
ISSN： 1944-8244
年卷期： 2024 年 16 卷 5 期
页码：
收录情况： SCI
摘要： Multidrug-resistant (MDR) pathogens pose a serious threat to the health and life of humans, necessitating the development of new antimicrobial agents. Herein, we develop and characterize a panel of nine amino acid peptides with a cation end motif. Bioactivity analysis revealed that the short peptide containing "RWWWR" as a central motif harboring mirror structure "KXR" unit displayed not only high activity against MDR planktonic bacteria but also a clearance rate of 92.33% +/- 0.58% against mature biofilm. Mechanically, the target peptide (KLR) killed pathogens by excessively accumulating reactive oxygen species and physically disrupting membranes, thereby enhancing its robustness for controlling drug resistance. In the animal model of sepsis infection by MDR bacteria, the peptide KLR exhibited strong therapeutic effects. Collectively, this study provided the dominant structure of short antimicrobial peptides (AMPs) to replenish our arsenals for combating bacterial infections and illustrated what could be harnessed as a new agent for fighting MDR bacteria.
分类号：
- 相关文献
作者其他论文 更多>>
-
The nematode effector calreticulin competes with the high mobility group protein OsHMGB1 for binding to the rice calmodulin-like protein OsCML31 to enhance rice susceptibility to Meloidogyne graminicola
作者：Liu, Jing;Zhang, Jiaqian;Wei, Ying;Su, Wen;Li, Wei;Wang, Bing;Dai, Liangying;Liu, Jing;Gheysen, Godelieve;Zhang, Jiaqian;Wei, Ying;Peng, Deliang;Peng, Huan;Peng, Huan;Dai, Liangying
关键词：calmodulin-like protein; calreticulin; effector; Meloidogyne graminicola; OsHMGB1; plant defense
-
Insight into the mechanism of nano-TiO2-doped biochar in mitigating cadmium mobility in soil-pak choi system
作者：Liu, Jing;Yang, Zhixing;Peng, Shirui;Lu, Dan;Li, Qiaoxian;Feng, Yaxuan;Chen, Kuiyuan;Wei, Yanyan;Liu, Jing;He, Tieguang;Yang, Zhixing;Zhu, Yanhuan;Li, Hong
关键词：Nanoparticles; Biochar; Cadmium; Microbial community; Soil metabolism; Soil remediation
-
A Review of the Mechanisms of Bacterial Colonization of the Mammal Gut
作者：Lin, Qingjie;Lin, Shiying;Fan, Zitao;Guo, Pingting;Liu, Jing;Ye, Dingcheng
关键词：bacterial colonization; intestine; adhesion; receptor; probiotics; pathogens; colonization resistance
-
Genome-wide identification of XTH gene family in Musa acuminata and response analyses of MaXTHs and xyloglucan to low temperature
作者：Tan, Yehuan;Zhan, Huiling;Chen, Houbin;Chen, Chengjie;Liu, Hui;Chen, Yilin;Zhao, Ziyue;Xiao, Yinyan;Liu, Jing;Zhao, Yafang;Xu, Chunxiang;Chen, Houbin;Li, Xiaoquan;Su, Zuxiang;Tan, Yehuan
关键词：
-
Orally Administered Lactobacillus rhamnosus CY12 Alleviates DSS-Induced Colitis in Mice by Restoring the Intestinal Barrier and Inhibiting the TLR4-MyD88-NF-κB Pathway via Intestinal Microbiota Modulation
作者：Zheng, Juanshan;Ahmad, Anum Ali;Yang, Chen;Liang, Zeyi;Liu, Jing;Ding, Xuezhi;Zheng, Juanshan;Ahmad, Anum Ali;Yang, Chen;Liang, Zeyi;Liu, Jing;Ding, Xuezhi;Zheng, Juanshan;Lan, Xianyong;Ahmad, Anum Ali;Shen, Wenxiang;Yan, Zuoting;Yang, Yayuan;Dong, Pengcheng;Ding, Xuezhi;Han, Jianlin;Han, Jianlin;Salekdeh, Ghasem Hosseini
关键词：Lactobacillus rhamnosusCY12; inflammatory bowel diseases; short-chain fattyacids; gut microbiota; DSS-inducedcolitis
-
Recapitulating familial hypercholesterolemia in a mouse model by knock-in patient-specific LDLR mutation
作者：Liu, Jing;Yang, Fayu;Shang, Lu;Cai, Shuo;Wu, Yuting;Liu, Yingchun;Zhang, Lifang;Fei, Chenzhong;Wang, Mi;Gu, Feng;Liu, Jing;Yang, Fayu;Shang, Lu;Cai, Shuo;Wu, Yuting;Liu, Yingchun;Zhang, Lifang;Fei, Chenzhong;Wang, Mi;Gu, Feng
关键词：ABE; atherosclerosis; gene editing; hypercholesterolemia; low-density lipoprotein receptor
-
A wild rice CSSL population facilitated identification of salt tolerance genes and rice germplasm innovation
作者：Xing, Meng;Nie, Yamin;Huang, Jingfen;Wang, Shizhuang;Wang, Yanyan;Chen, Wenxi;Chen, Ziyi;Zhang, Lifang;Cheng, Yunlian;Yang, Qingwen;Sun, Jiaqiang;Qiao, Weihua;Xing, Meng;Nie, Yamin;Huang, Jingfen;Wang, Shizhuang;Wang, Yanyan;Chen, Ziyi;Yang, Qingwen;Qiao, Weihua;Li, Yapeng;Zhao, Mingchao
关键词：
