Transcriptomic analysis uncovers a biphasic response to precocious Eimeria acervulina infection in chicken duodenal tissue

文献类型： 外文期刊

第一作者： Zhang, Ning

作者： Zhang, Ning;Liu, Jie;Chen, Linlin;Zhang, Sixin;Liu, Xianyong;Gu, Xiaolong;Suo, Xun;Zhang, Yuanyuan;Zhang, Yuanyuan;Tang, Xinming;Gu, Xiaolong;Chen, Shiyi

作者机构：

关键词： Eimeria acervulina; Precocious line; Dual RNA-seq analysis; Immune response; Lipid metabolic

期刊名称：VETERINARY PARASITOLOGY （ 影响因子：2.0； 五年影响因子：2.4 ）

ISSN： 0304-4017

年卷期： 2024 年 331 卷

页码：

收录情况： SCI

摘要： Live anticoccidial vaccines, either formulated with unattenuated or attenuated Eimeria parasites, are powerful stimulators of chicken intestinal immunity. Little is known about the dynamics of gene expression and the corresponding biological processes of chicken responses against infection with precocious line (PL) of Eimeria parasites. In the present study, we performed a time-series transcriptomic analysis of chicken duodenum across 15 time points from 6 to 156 hours post-infection (p.i.) with PL of E. acervulina. A high-quality profile showing two distinct changes in chicken duodenum mRNA expression was generated during the infection of Eimeria. Early response revealed that activation of the chicken immune response was detectable from 6 h.p.i., prominent genes triggered during the initiation of asexual and sexual parasite growth encompass immune regulatory effects, such as interferon gamma (IFN-gamma), interferon regulatory factor 1 (IRF1), and interleukin-10 (IL10). The late response was identified significantly associating with maintaining cellular structure and activating lipid metabolic pathways. These analyses provide a detailed depiction of the biological response landscape in chickens infected by the PL of E. acervulina, contributing significant insights for the investigation of the host-parasite interactions and the management of parasitic diseases.

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