Surface structure change properties: Auto-soft bionic fibrous membrane in reducing postoperative adhesion

文献类型： 外文期刊

第一作者： Xu, Shanshan

作者： Xu, Shanshan;Lin, Zhenyu;Han, Charles C.;Wang, Chenhong;Wang, Heran;Mao, Ruoqing;Liang, Xiaoyu;Li, Jiangxue;Li, Shilin;Liu, Ying;Mao, Ruoqing;Liang, Xiaoyu;Li, Jiangxue;Li, Shilin;Liu, Ying;Mao, Ruoqing;Jiang, Jipeng;Ma, Yongfu;Liu, Yang;Zhang, Tongshuo;Liu, Ying

作者机构：

关键词： Fibrous membrane; Anti-adhesion; Surface; Electrospun; Biocompatibility

期刊名称：BIOACTIVE MATERIALS （ 影响因子：16.874； 五年影响因子：17.363 ）

ISSN：

年卷期： 2022 年 12 卷

页码：

收录情况： SCI

摘要： Peritoneal adhesion is the most common adverse effect following abdominal surgery or inflammation. The occurrence in clinical trials has been successfully reduced using barriers. However, the shortcomings of frequently used adhesion barriers, such as rapid degradation rate of gel barrier and inadequate operation ability of solid barrier, cannot be ignored. In this study, a fibrous membrane with an ECM-like structure was prepared. The adhesion properties were reduced significantly by changing the surface structure. The fibrous membrane caused less inflammatory response and much less peripheral adhesion and intestinal obstruction compared to the casting film and the commercial film with smooth surface, though with the same components. Because of the auto-soft bionic structure and similarity in the mechanical modulus of the tissues, the fibrous membrane was more flexible when it adhered to the tissues, showed excellent effectiveness and biocompatibility. In addition to the rat and miniature pig models, a randomized, placebo-controlled, and multicenter clinical pilot study with 150 patients confirmed that because of its flexibility, biodegradability, and similarity to mechanical modulus and structure with tissues involved, the fibrous membrane served as a favorable implant for preventing postoperation adhesion.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序