Elucidating the role of DNA methylation in low-salinity adaptation of the swimming crab Portunus trituberculatus

文献类型： 外文期刊

第一作者： Guo, Junyang

作者： Guo, Junyang;Lv, Jianjian;Sun, Dongfang;Liu, Ping;Gao, Baoquan;Guo, Junyang;Lv, Jianjian;Liu, Ping;Gao, Baoquan

作者机构：

关键词： Portunus trituberculatus; DNA methylation; Gill; Low salinity; Molecular mechanisms

期刊名称：AQUACULTURE （ 影响因子：3.9； 五年影响因子：4.4 ）

ISSN： 0044-8486

年卷期： 2025 年 595 卷

页码：

收录情况： SCI

摘要： The swimming crab Portunus trituberculatus holds significant economic value in the aquaculture industry in China. Salinity is an important environmental factor that affects its growth and susceptibility to diseases. DNA methylation, a well-studied epigenetic mechanism, plays a pivotal role in the stress response of organisms. Herein we performed whole-genome bisulfite sequencing (WGBS) to assess changes in DNA methylation patterns in P. trituberculatus gill tissues before and after exposure to low-salinity stress. Overall, 33,712 differentially methylated regions (DMRs) were screened and 3546 functional genes were identified, many of which were notably enriched in pathways related to, for example, proteolysis and amino acid metabolism. By integrating WGBS and previous RNA-seq data, we identified 187 overlapping genes between differentially expressed genes and differentially methylated genes. Our findings reveal molecular mechanisms via which DNA methylation participates in low-salinity adaptation by regulating gene expression. Moreover, our data provide preliminary evidence of the substantial role of DNA methylation in facilitating salinity adaptation in P. trituberculatus and contribute to a systematic understanding of the mechanisms underpinning low-salinity adaptation in this species.

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