Herbicidal Sorbicillinoid Analogs Cause Lignin Accumulation in Aspergillus aculeatus TE-65L

文献类型： 外文期刊

第一作者： Huang, Xin-Rong

作者： Huang, Xin-Rong;Jiang, Chao-Nan;Wang, Hai-Su;Gu, Gan;Wang, Mei;Sui, Xiao-Na;Zhang, Zhong-Feng;Zhang, Peng;Zhao, Dong-Lin;Huang, Xin-Rong;Si, Tong

作者机构：

关键词： sorbicillinoid derivatives; herbicidal activity; phenylpropanoid biosynthesis pathway; modes of action; lignin accumulation

期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：6.2； 五年影响因子：6.4 ）

ISSN： 0021-8561

年卷期： 2024 年 72 卷 38 期

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收录情况： SCI

摘要： Five new sorbicillinoid derivatives, including (+/-)-aspersorbicillin A [(+/-)-1], a pair of enantiomers at C-9, and aspersorbicillins B-D (2-4), together with two known analogs (5 and 6) were isolated from the endophytic fungus Aspergillus aculeatus TE-65L. Their structures including absolute configurations were determined by detailed spectroscopic analyses and electronic circular dichroism calculations. The herbicidal activity of sorbicillinoids on the germ and radicle elongation of various weed types was reported for the first time. Compound 1 displayed significant herbicidal activity against Eleusine indica germ elongation (IC50 = 28.8 mu g/mL), while compound 6 inhibited radicle elongation (IC50 = 25.6 mu g/mL). Both were stronger than those of glyphosate (66.2 and 30.9 mu g/mL, respectively). Further transcriptomic and LC-MS/MS metabolomic analysis indicated that 6 induced the transcriptional expressions of genes related to the lignin biosynthetic pathway, resulting in lignin accumulation. Transmission electron microscopy confirmed the cell wall thickening of seeds treated with 6, suggesting weed growth inhibition. This study reveals new lead compounds for fabricating natural herbicides and expands the agricultural use of sorbicillinoid analogs.

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