Two new monoterpene lactones from Ligularia rumicifolia (JRDrumm.) SWLiu and their anti-proliferative activities

文献类型： 外文期刊

第一作者： Zhang, Jing

作者： Zhang, Jing;Jiang, Wei;Qu, Yanbo;Liao, Zhi-Xin;Zhang, Jing;Cao, Hong-Jie;Liu, Chao;Sun, Jin-Yue

作者机构：

关键词： Ligularia rumicifolia (JRDrumm.) SWLiu; Monoterpene lactones; Anti-proliferative

期刊名称：PHYTOCHEMISTRY LETTERS （ 影响因子：1.679； 五年影响因子：1.861 ）

ISSN： 1874-3900

年卷期： 2018 年 28 卷

页码：

收录情况： SCI

摘要： A phytochemical study of the EtOAc extract of Ligularia rumicifolia (J.R.Drumm.) S.W.Liu led to the isolation of two new monoterpene lactones (1-2) named (2S,3S,5R)-5-ethyl-2,3-dimethyl-6-oxoterahydro-2H-pyran-2-carboxylic acid and (2S,3S,5R)-5-ethyl-2,3-dimethyl-6-oxoterahydro-2H-pyran-2-carboxylic acid methyl ester, along with nine known compounds (3-11). All compounds were isolated from this species for the first time. Their structures were established on the basis of spectroscopic methods. The cytotoxic activity of Compound 2 was weak, with the lowest IC50 value of 80.84 mu M against MCF-7 cells. Compound 1 exhibited better anti-proliferative activities against MCF-7, T-24, HepG-2 and SKOV-3 cell lines than Compound 2, with the lowest IC50 value of 66.12 mu M against MCF-7 cells.

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[1]Two new monoterpene lactones from Ligularia rumicifolia (JRDrumm.) SWLiu and their anti-proliferative activities. Zhang, Jing,Jiang, Wei,Qu, Yanbo,Liao, Zhi-Xin,Zhang, Jing,Cao, Hong-Jie,Liu, Chao,Sun, Jin-Yue. 2018

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