Cell binding tropism of rat hepatitis E virus is a pivotal determinant of its zoonotic transmission to humans

文献类型： 外文期刊

第一作者： Guo, Hongbo

作者： Guo, Hongbo;Xu, Jiaqi;Li, Chunyang;Hou, Yao;Wang, Lingli;Li, Zheng;Wang, Zijie;Ding, Yibo;Zeng, Dou;Zhang, Jikai;Ding, Xiaohui;Tang, Renxian;Zheng, Kuiyang;Wang, Wehshi;Situ, Jianwen;Wu, Shusheng;Miao, Weiwei;Sridhar, Siddharth;Wang, Xia;Yang, Guangde;Pan, Xiucheng;Ying, Dong;Zheng, Zizheng;Su, Jia;Su, Jia;Zhou, Peng;Lu, Yihan;Kong, Huihui

作者机构：

关键词： hepatitis E virus; |zoonosis; cell binding tropism; virus entry

期刊名称：PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA （ 影响因子：9.1； 五年影响因子：10.6 ）

ISSN： 0027-8424

年卷期： 2024 年 121 卷 45 期

页码：

收录情况： SCI

摘要： Classically, all hepatitis E virus (HEV) variants causing human infection belong to the genus Paslahepevirus (HEV- A). However, the increasing cases of rat HEV infection in humans since 2018 challenged this dogma, posing increasing health threats. Herein, we investigated the underlying mechanisms dictating the zoonotic potentials of different HEV species and their possible cross- protection relationships. rat HEV particles penetrated the cell membrane and entered human target cells postbinding. In contrast, ferret HEVVLPs showed marginal cell binding and entry ability, bat HEVVLPs and avian HEVVLPs exhibited no binding and entry potency. Structure- based three- dimensional mapping identified that the surface spike domain of rat HEV is crucial for cell binding. Antigenic cartography indicated that rat HEV exhibited partial cross- reaction with HEV- A. Intriguingly, sera of HEV- A infected patients or human HEV vaccine Hecolin (R) immunized individuals provided partial cross- protection against the binding of rat HEVVLPs to human target cells. In summary, the interactions between the viral capsid and cellular receptor(s) regulate the distinct zoonotic potentials of different HEV species. The systematic characterization of antigenic cartography and serological cross- reactivity of different HEV species provide valuable insights for the development of species- specific diagnosis and protective vaccines against zoonotic HEV infection.

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