Molecular genetic foundation of a sex-linked tailless trait in Hongshan chicken by whole genome data analysis

文献类型： 外文期刊

第一作者： Chen, Anqi

作者： Chen, Anqi;Zhao, Xiurong;Wang, Gang;Zhang, Xinye;Ren, Xufang;Zhang, Yalan;Cheng, Xue;Yu, Xiaofan;Mei, Xiaohan;Guo, Menghan;Jiang, Xiaoyu;Ning, Zhonghua;Qu, Lujiang;Wang, Huie;Qu, Lujiang;Jiang, Runshen;Guo, Xing;Wang, Qiong;Wang, Xue;Wei, Guozhen

作者机构：

关键词： chicken; rumplessness; Pool-GWAS

期刊名称：POULTRY SCIENCE （ 影响因子：4.4； 五年影响因子：4.4 ）

ISSN： 0032-5791

年卷期： 2024 年 103 卷 6 期

页码：

收录情况： SCI

摘要： As a Chinese local chicken breed, Hongshan chickens have 2 kinds of tail feather phenotypes, normal and taillessness. Our previous studies showed that taillessness was a sex-linked dominant trait. Abnormal development of the tail vertebrae could be explained this phenomenon in some chicken breeds. However, the number of caudal vertebrae in rumpless Hongshan chickens was normal, so rumplessness in Hongshan chicken was not related to the development of the caudal vertebrae. Afterwards, we found that rumplessness in Hongshan was due to abnormal development of tail feather rather than abnormal development of caudal vertebrae. In order to understand the genetic foundation of the rumplessness of Hongshan chickens, we compared and reanalyzed 2 sets of data in normal and rumpless Hongshan chickens from our previous studies. By joint analysis of genome-wide selection signature analysis and genome-wide association approach, we found that 1 overlapping gene (EDIL3) and 16 peak genes (ENSGALG00000051843, ENSGALG00000053498, ENSGALG00000054800, KIF27, PTPRD, ENSGALG00000047579, ENSGALG00000041052, ARHGEF28, CAMK4, SERINC5, ENSGALG00000050776, ERCC8, MCC, ADAMTS19, ENSGALG00000053322, CHRNA8) located on the Z chromosome was associated with the rumpless trait. The results of this study furtherly revealed the molecular mechanism of the rumpless trait in Hongshan chickens, and identi fied the candidate genes associated with this trait. Our results will help to improve the shape of chicken tail feathers and to rise individual economic value in some speci fic market in China.

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