Pigs? intestinal barrier function is more refined with aging

文献类型： 外文期刊

第一作者： Yang, Shanshan

作者： Yang, Shanshan;Yang, Ning;Huang, Xin;Li, Yang;Liu, Guo;Liu, Guangliang;Yang, Shanshan;Jansen, Christine A.;Savelkoul, Huub F. J.;Yang, Ning;Li, Yang;Liu, Guangliang

作者机构：

关键词： Piglets; Enteric virus; Susceptibility; Ages; Intestinal environment

期刊名称：DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY （ 影响因子：3.605； 五年影响因子：3.833 ）

ISSN： 0145-305X

年卷期： 2022 年 136 卷

页码：

收录情况： SCI

摘要： The high mortality upon enteric virus infection in piglets causes huge economic losses. To control these in-fections, potential causes for this high susceptibility for enteric virus infections in younger piglets were analyzed by comparing the intestinal barrier between 1-week, 2-week and 4-week-old piglets. In this study, histological staining was used to analyze morphological differences in intestinal villi, real-time qPCR was performed to assess mRNA expression levels of genes that were related to viral infection and differentiation of immune cells, and flow cytometry was utilized to measure the frequencies of T cells. According to the results obtained, 1-week-old piglets have intestinal villi with shallower crypts, less well developed epithelial cells and a more immature immune system compared to older pigs. Moreover, high amounts of enteric virus invasion-assisting proteins but low amounts of resistant proteins in 1-week piglets could also be a reason for the high susceptibility of 1 -week-old piglets.

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