Green tea peptides ameliorate diabetic nephropathy by inhibiting the TGF-beta/Smad signaling pathway in mice

文献类型： 外文期刊

第一作者： Chen, Xuhui

作者： Chen, Xuhui;Li, Dongli;Sun, Lingli;Lai, Xingfei;Wen, Shuai;Chen, Ruohong;Zhang, Zhenbiao;Li, Qiuhua;Sun, Shili;Li, Dongli

作者机构：

期刊名称：FOOD & FUNCTION （ 影响因子：6.317； 五年影响因子：6.375 ）

ISSN： 2042-6496

年卷期： 2022 年 13 卷 6 期

页码：

收录情况： SCI

摘要： Diabetic nephropathy (DN) is the most important cause of middle and late-stage chronic kidney disease. Green tea polypeptides are extracted from tea pomace, and exhibit various pharmacological effects. In this study, we analyzed the reno-protective effects of green tea peptides in diabetic db/db mice, and explored the underlying mechanisms. Peptide treatment for 5 weeks significantly reduced the blood glucose levels and other indices of diabetes, and alleviated renal injury measured in terms of blood creatinine, urea nitrogen and urinary albumin/urinary creatinine levels. Mechanistically, the green tea peptides downregulated p-Smad2/3, alpha-SMA, ZO-1 and vimentin proteins in the kidney tissues, and elevated Smad7. Thus, green tea peptides inhibited the deposition of ECM proteins by suppressing excessive activation of the TGF-beta/Smad signaling pathway and reducing fibronectin levels. On the other hand, tea peptides ameliorated renal injury by inhibiting the production of inflammatory factors (iNOS and TNF-alpha) by suppressing the NF-kappa B signaling pathway. In addition, we confirmed the inhibitory effect of green tea peptides on the TGF-beta/Smad signaling pathway in TGF-beta 1-stimulated HK-2 cells. Therefore, tea peptides can be considered as an effective candidate for alleviating DN.

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