Comparison of twelve human milk oligosaccharides in mature milk from different areas in China in the Chinese Human Milk Project (CHMP) study

文献类型： 外文期刊

第一作者： Zhang, Wenyuan

作者： Zhang, Wenyuan;Vervoort, Jacques;Gao, Peng;Zhu, Huiquan;Wang, Xiaodan;Zhang, Yumeng;Chen, Baorong;Pang, Xiaoyang;Zhang, Shuwen;Lu, Jing;Lyu, Jiaping;Pan, Jiancun;Liu, Ying;Li, Yuanyuan;Jiang, Shilong;Zhang, Wenyuan;Vervoort, Jacques;Lu, Jing;Pan, Jiancun;Liu, Ying;Li, Yuanyuan;Jiang, Shilong

作者机构：

关键词： Human milk oligosaccharides; Lactation; Latitude; Geography; Maternal diet; Environment factors

期刊名称：FOOD CHEMISTRY （ 影响因子：9.231； 五年影响因子：8.795 ）

ISSN： 0308-8146

年卷期： 2022 年 395 卷

页码：

收录情况： SCI

摘要： Human milk oligosaccharides (HMOs) act as a vital role in the development of infant's gut microbiome and immune function. This study aimed to measure 12 oligosaccharides in milk from Chinese donors (n = 203), and evaluated the influences of multiple factors on the HMOs profiles. The results indicated that concentrations of 6 ' sialyllactose were the highest among 12 oligosaccharides (2.31 +/- 0.81 g/L). HMOs concentrations varied depending on geographical location. Latitude was observed to be related to concentrations of Lacto-N-neohexaose, lacto-N-fucopentaose III, 3 '-sialyllactose (r = -0.67, r = +0.63 and r = +0.50, respectively). Environmental factors like seasons correlated with lacto-N-difucohexaose II, Lacto-N-neohexaose and 2 '-fucosyllactose (r = -0.47, r = -0.4, r = -0.35, respectively). Several HMOs concentrations were correlated with maternal diet. As a consequence, the HMOs profiles measured were influenced by geographical, environmental, maternal anthropometric as well as dietary factors.

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