Molecular cloning and functional characterization of a novel isoform of chicken myeloid differentiation factor 88 (MyD88)

文献类型： 外文期刊

第一作者： Qiu, Yafeng

作者： Qiu, Yafeng;Shen, Yang;Li, Xiangdong;Ding, Chan;Ma, Zhiyong

作者机构：

关键词： MyD88;cDNA cloning;NF-kappa B;chicken;gene expression;KAPPA-B ACTIVATION;INNATE IMMUNITY;RECEPTOR;FAMILY;EXPRESSION;PATHOGEN;SEQUENCE;MEMBER

期刊名称：DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY （ 影响因子：3.636； 五年影响因子：3.654 ）

ISSN：

年卷期：

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收录情况： SCI

摘要： Myeloid differentiation factor 88 (MyD88) is an adaptor protein involved in the interteukin-1 receptor- and Toll-like receptor-induced activation of nuclear factor-kappa B (NF-kappa B). A novel isoform of chicken MyD88, designated chicken MyD88-2, has been cloned and functionally characterized. Its open reading frame is of length 900 bp, and it encodes a predicted 299 residue protein, similar in length to its mammalian orthologues, but, respectively, 77 and 69 amino acids shorter than the previously described chicken MyD88-1 and -3. The amino acid sequence of chicken MyD88-2 displays 96.9%, 96.9%, 70.4% and 70.2% identity with, respectively, chicken MyD88-1, -3, human and mouse MyD88. Chicken MyD88-2 expression was detected in a range of tissues tested, but no expression of either chicken MyD88-1 or -3 was observed. The over-expression of chicken MyD88-2 significantly induced the activation of NF-kappa B in vitro, suggesting that chicken MyD88-2 plays an important rote in the innate immune responses of chicken. (C) 2008 Elsevier Ltd. All rights reserved.

分类号： R36

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