Biological functions of microRNAs: a review

文献类型: 外文期刊

第一作者: Huang, Yong

作者: Huang, Yong;Shen, Xing Jia;Wang, Sheng Peng;Tang, Shun Ming;Zhang, Guo Zheng;Zou, Quan;Huang, Yong;Shen, Xing Jia;Wang, Sheng Peng;Tang, Shun Ming;Zhang, Guo Zheng

作者机构:

关键词: MicroRNA;Biogenesis;Function;Expression;Disease

期刊名称:JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY ( 影响因子:4.158; 五年影响因子:3.617 )

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收录情况: SCI

摘要: MicroRNAs (miRNAs) are a recently discovered family of endogenous, noncoding RNA molecules approximately 22 nt in length. miRNAs modulate gene expression post-transcriptionally by binding to complementary sequences in the coding or 3' untranslated region of target messenger RNAs (mRNAs). It is now clear that the biogenesis and function of miRNAs are related to the molecular mechanisms of various clinical diseases, and thatthey can potentially regulate every aspect of cellular activity, including differentiation and development, metabolism, proliferation, apoptotic cell death, viral infection and tumorgenesis. Here, we review recent advances in miRNA research, and discussthe diverse roles of miRNAs in disease.

分类号: Q4

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