Simultaneous enantioselective determination of fenbuconazole and its main metabolites in soil and water by chiral liquid chromatography/tandem mass spectrometry

文献类型： 外文期刊

第一作者： Dong, Fengshou

作者： Dong, Fengshou;Liu, Xingang;Xu, Jun;Li, Jing;Kong, Zhiqiang;Chen, Xiu;Zheng, Yongquan;Song, Wencheng;Wang, Yunhao

作者机构：

关键词： Chirality;Enantiomers;Enantioselectivity;Fenbuconazole;LC-MS/MS;Metabolite

期刊名称：JOURNAL OF CHROMATOGRAPHY A （ 影响因子：4.759； 五年影响因子：4.302 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： A novel and sensitive method was developed for the simultaneous determination of fenbuconazole and its main metabolites enantioselectively using chiral liquid chromatography coupled with tandem mass spectrometry. The separation and determination were performed using reversed-phase chromatography on a cellulose chiral stationary phase, a Chiralcel OD-RH (150mm×4.6mm) column, under isocratic conditions at 0.5mL/min flow rate. The effects of three cellulose-based columns and three amylose-based columns on the separation were also investigated. The elution orders of the eluting enantiomers were identified by an optical rotation detector. The QuEChERS (acronym for Quick, Easy, Cheap, Effective, Rugged and Safe) method and solid-phase extraction (SPE) were used for the extraction and clean-up of the soil and water samples, respectively. Parameters including the matrix effect, linearity, precision, accuracy and stability were evaluated. Under optimal conditions, the mean recoveries for all enantiomers from the soil samples were 82.5-104.1% with 2.7-9.5% intra-day relative standard deviations (RSD) and 5.7-11.2% inter-day RSD at 5, 25 and 50μg/kg levels; the mean enantiomer recoveries from the water samples were 81.8-104.6% with 2.6-11.4% intra-day RSD and 5.3-10.4% inter-day RSD at 0.25, 0.5 and 2.5μg/L levels. Coefficients of determination R~2≥0.9991 were achieved for each enantiomer in the soil and water matrix calibration curves within the range of 1.0-125μg/L. The limits of detection (LOD) for all enantiomers in the soil and water were less than 0.8μg/kg, whereas the limit of quantification (LOQ) did not exceed 2.5μg/kg. The results of the method validation confirm that this proposed method is convenient and reliable for the enantioselective determination of the enantiomers of fenbuconazole and its main metabolites in soil and water.

分类号： O65

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